TkA02G350990 | RubberDandelionOmics

Gene overview

TkA02G350990

Reference: TK1151 Chr: Chr02 Coordinates: 89276533-89280351 Strand: + Type: protein_coding

cDNA / CDS / Protein Sequences

Available sequence downloads CDS FASTA Protein FASTA cDNA FASTA

cDNA

2693 bp · TkA02G350990|TK1151|cDNA

AAATAGTCTCAATAAAATGTCGTTGACGGTAACAGACGTTTCGTAAAGGATATTGGGTCAAGAAGAAGCAACCCCAGCCTGAGAAATCGATAGAGAGACTCAAATTCTTCACAAAACAATTATTCACAAAACCCCACAAATTCTTTCGTCTGCTCAAATCAAAGATCCCTTTTTAAATAAATGGTGAATAATTTACAAGTTATTTCACTGTAATGAGAATGAGAGGACCTATAATTTCACTTTTGCGCCTTTTGGCCGTG...

CDS

Download CDS FASTA

2475 bp · TkA02G350990|TK1151|CDS

ATGAGAATGAGAGGACCTATAATTTCACTTTTGCGCCTTTTGGCCGTGATTCCAGCGGCATATGGGAGTCTGCCGGTCCTCCCGCCGCCGTCAACAACTTCCGGTTCCTCTGTTCTGGATCAATTTCAGCTTCCGCCGCCGCTTCCAGCTAAGATCAACTCAACACCTAAACAGGATGCTATATTGGTGGCTGCTCCAGATGGCACATTATATCAAGTAGATATCAGTTCAGGTAAAATTCTTTGGTCTTTCCCATCTGG...

Protein

Download Protein FASTA

824 aa · TkA02G350990|TK1151|PROTEIN

MRMRGPIISLLRLLAVIPAAYGSLPVLPPPSTTSGSSVLDQFQLPPPLPAKINSTPKQDAILVAAPDGTLYQVDISSGKILWSFPSGAPIYDSQQSPNLEDDEHNSSRQKHNKFYIDCGDDWQLYIHSKDSKAEKLPFGAEELIGRTPHVSVDGVLLGSKKTTVFLVDPQTGKIVYTFKSNGGQSPENSSIILKKDADKWKEPTTLGFDHVDHDQLLYIKRFDYELTYSSSTTGNVLWYLMFADFEASQCHGSNTFLGGM...

Flanking Sequence Download

Sequence orientation and download details

Upstream/downstream are capped at 10000 bp per side. Negative-strand genes are reverse-complemented so the final FASTA follows transcriptional 5′→3′ orientation.

ID Mapping

Input ID	`TkA02G350990`
TK1151 ID	TkA02G350990
OH-1004 ID	LXL04_015261
Relationship / confidence	Rbh High Identity Coverage Synteny / Strict
Protein identity (%)	99.300
Protein coverage (%)	TK1151 100.000 / OH-1004 96.479 Coverage and evidence Coverage is the aligned span of the best-scoring HSP divided by representative protein length. A homolog match does not establish functional validation.
Source version	TK1151 / GWHBCHF00000000

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SNP / Indel variants and carrier samplesCRA009020 · TK1151

Expand to load variant records for this gene.

Basic Information and Functional Annotation

Gene ID TkA02G350990

Location Chr02:89276533-89280351 (+)

Description Similar to IRE1B: Serine/threonine-protein kinase/endoribonuclease IRE1b

Arabidopsis / Rice Reference Genes and Papers

Download references for this gene

Arabidopsis

Reference gene ID	Possible function	Papers / DOI
`At5g24360`	Senses unfolded proteins in the lumen of the endoplasmic reticulum via its N-terminal domain which leads to enzyme auto- activation.	Heat induces the splicing by IRE1 of a mRNA encoding a transcription factor involved in the unfolded protein response in Arabidopsis.2011 · DOI: 10.1073/pnas.1102117108 AtIRE1A/AtIRE1B and AGB1 independently control two essential unfolded protein response pathways in Arabidopsis.2012 · DOI: 10.1111/j.1365-313x.2011.04788.x Arabidopsis IRE1 catalyses unconventional splicing of bZIP60 mRNA to produce the active transcription factor.2011 · DOI: 10.1038/srep00029 IRE1/bZIP60-mediated unfolded protein response plays distinct roles in plant immunity and abiotic stress responses.2012 · DOI: 10.1371/journal.pone.0031944 Alteration of the bZIP60/IRE1 pathway affects plant response to ER stress in Arabidopsis thaliana.2012 · DOI: 10.1371/journal.pone.0039023 Degradation of the endoplasmic reticulum by autophagy during endoplasmic reticulum stress in Arabidopsis.2012 · DOI: 10.1105/tpc.112.101535
`At2g17520`	Senses unfolded proteins in the lumen of the endoplasmic reticulum via its N-terminal domain which leads to enzyme auto- activation.	Characterization of two homologs of Ire1p, a kinase/endoribonuclease in yeast, in Arabidopsis thaliana.2002 · DOI: 10.1016/s0167-4781(02)00237-3 AtIRE1A/AtIRE1B and AGB1 independently control two essential unfolded protein response pathways in Arabidopsis.2012 · DOI: 10.1111/j.1365-313x.2011.04788.x Arabidopsis IRE1 catalyses unconventional splicing of bZIP60 mRNA to produce the active transcription factor.2011 · DOI: 10.1038/srep00029 IRE1/bZIP60-mediated unfolded protein response plays distinct roles in plant immunity and abiotic stress responses.2012 · DOI: 10.1371/journal.pone.0031944
`At3g11870`	Inactive serine/threonine-protein kinase/endoribonuclease IRE1-like.	No verified direct reference in this release

Rice

Reference gene ID	Possible function	Papers / DOI
`Os07g0471000`	Involved in endoplasmic reticulum (ER) stress response.	Signal transduction by IRE1-mediated splicing of bZIP50 and other stress sensors in the endoplasmic reticulum stress response of rice.2012 · DOI: 10.1111/j.1365-313x.2011.04844.x Conservation of IRE1-regulated bZIP74 mRNA unconventional splicing in rice (Oryza sativa L.) involved in ER stress responses.2012 · DOI: 10.1093/mp/ssr115

Functional annotation source

View annotation sources

Functional annotation source: OH1004 · LXL04_015261 · GCA_047496595.1_OSU_TarKok_2.0. These OH1004 annotations are retrieved through ID mapping; the Arabidopsis/rice table below uses protein alignments from the query reference.

GO annotations (OH1004 source)

GO:0000394 RNA splicing, via endonucleolytic cleavage and ligation Biological Process

GO:0002376 immune system process Biological Process

GO:0006351 DNA-templated transcription Biological Process

GO:0006397 mRNA processing Biological Process

GO:0006914 autophagy Biological Process

GO:0006986 response to unfolded protein Biological Process

GO:0008380 RNA splicing Biological Process

GO:0009751 response to salicylic acid Biological Process

GO:0030968 endoplasmic reticulum unfolded protein response Biological Process

GO:0034263 positive regulation of autophagy in response to ER overload Biological Process

GO:0034976 response to endoplasmic reticulum stress Biological Process

GO:0036498 IRE1-mediated unfolded protein response Biological Process

KEGG gene cross-reference

ath:AT2G17520

ath:AT3G11870

ath:AT5G24360

dosa:Os07g0471000

These KEGG gene identifiers are linked through homologous proteins; they do not establish pathway function for this gene.

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Gene expression

View expression in different studies, tissues and treatments. Results are presented separately by study and measurement unit.

View expression for this gene

Data sources and gene correspondence

Expression data come from public transcriptome studies. Reference genomes, sample metadata and measurement units are shown with the results. Ambiguous cross-reference correspondences do not select an expression record automatically; missing values do not mean zero expression.

Subcellular Localization Top 5

Computational predictions or homology annotations below do not replace localization experiments.

Endoplasmic reticulum0.543

Rank 1 · TkA02G350990 · TK1151

Golgi apparatus0.208

Rank 2 · TkA02G350990 · TK1151

Nucleus0.133

Rank 3 · TkA02G350990 · TK1151

Cytoplasm0.126

Rank 4 · TkA02G350990 · TK1151

Cell membrane0.081

Rank 5 · TkA02G350990 · TK1151

LocPro · Direct prediction · Computational prediction, not experimental localization

Open Subcellular Module

Predicted Functional Domains

Domain results are from Pfam-A/HMMER; positions are amino-acid coordinates on the protein sequence.

PF13570Beta-prop_ACSF437-182 aa

PF13360PQQ_257-173 aa

PF25292Beta-prop_CGLA57-91 aa

PF01011PQQ58-89 aa

PF25171Beta-prop_WDR36-Utp21_1st60-99 aa

PF07774EMC1_C61-180 aa

PF22112OmcA-like_N113-194 aa

PF01011PQQ142-234 aa

Gene ID	Domain ID	Domain Name	Start aa	End aa	E-value	Score
TkA02G350990	`PF13570`	Beta-prop_ACSF4	37	182	3e-05	24.3
TkA02G350990	`PF13360`	PQQ_2	57	173	0.00073	20.0
TkA02G350990	`PF25292`	Beta-prop_CGLA	57	91	0.0064	16.7
TkA02G350990	`PF01011`	PQQ	58	89	0.026	14.0
TkA02G350990	`PF25171`	Beta-prop_WDR36-Utp21_1st	60	99	0.027	14.6
TkA02G350990	`PF07774`	EMC1_C	61	180	0.11	12.5
TkA02G350990	`PF22112`	OmcA-like_N	113	194	0.095	13.3
TkA02G350990	`PF01011`	PQQ	142	234	0.026	14.0
TkA02G350990	`PF13360`	PQQ_2	149	183	0.00073	20.0
TkA02G350990	`PF25171`	Beta-prop_WDR36-Utp21_1st	152	182	0.027	14.6
TkA02G350990	`PF13570`	Beta-prop_ACSF4	212	250	3e-05	24.3
TkA02G350990	`PF07714`	PK_Tyr_Ser-Thr	416	682	1.3e-30	107.3
TkA02G350990	`PF00069`	Pkinase	417	687	1.3e-40	140.2
TkA02G350990	`PF17667`	Pkinase_fungal	529	619	5.2e-06	26.2
TkA02G350990	`PF06293`	Kdo	531	571	0.052	13.7
TkA02G350990	`PF03109`	ABC1	539	583	0.33	10.8

Arabidopsis / Rice Protein Homology

Only Arabidopsis and rice are shown. Swiss-Prot entries are reviewed; TrEMBL entries are supplementary sequence candidates. Similarity is not experimental validation.

Download current result

Protein	Organism	Description	Identity	Database	Confidence
`Q93VJ2`	Arabidopsis thaliana	sp\|Q93VJ2\|IRE1B_ARATH Serine/threonine-protein kinase/endoribonuclease IRE1b	46.200%	Swiss-Prot	Medium
`Q9C5S2`	Arabidopsis thaliana	sp\|Q9C5S2\|IRE1A_ARATH Serine/threonine-protein kinase/endoribonuclease IRE1a	43.400%	Swiss-Prot	Medium
`Q9SF12`	Arabidopsis thaliana	sp\|Q9SF12\|IRE1L_ARATH Inactive serine/threonine-protein kinase/endoribonuclease IRE1-like	43.300%	Swiss-Prot	Medium
`Q7XIT1`	Oryza sativa subsp. japonica	sp\|Q7XIT1\|IRE1_ORYSJ Serine/threonine-protein kinase/endoribonuclease IRE1	39.200%	Swiss-Prot	Medium

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