LXL04_003014 | RubberDandelionOmics

基因概览

LXL04_003014

当前版本: OH-1004 染色体: Chr01 坐标: 64987114-64995744 链方向: + 类型: protein_coding

cDNA / CDS / 蛋白序列

可用序列下载 CDS FASTA 蛋白 FASTA cDNA FASTA

cDNA

2991 bp · LXL04_003014|LXL04_003014|OH1004|cDNA

ATGGCTTTGGATTCAGTTCGTTTGGCAGGTGGAAAGAAAACGTTAGAAGCGGGTGGCTTTGTTCTCTTGGTCGGTGGAGATGCCTCTTTGAACAAAGGTGATCGGAAGAGGTTAAAGAATACTTTGGGCATGATCTGGGTGAAGGTCGATGTCCGGGAGAAGGTTGAGATGATTCCAAAGAAGacgttgttgctgttgctgGAGCGTATAAAAGGAACGGAAAAAATGGAGGACGTTCAAGGTAGTTTATTGTTGGCTAG...

CDS

下载 CDS FASTA

2991 bp · LXL04_003014|LXL04_003014|OH1004|CDS

ATGGCTTTGGATTCAGTTCGTTTGGCAGGTGGAAAGAAAACGTTAGAAGCGGGTGGCTTTGTTCTCTTGGTCGGTGGAGATGCCTCTTTGAACAAAGGTGATCGGAAGAGGTTAAAGAATACTTTGGGCATGATCTGGGTGAAGGTCGATGTCCGGGAGAAGGTTGAGATGATTCCAAAGAAGACGTTGTTGCTGTTGCTGGAGCGTATAAAAGGAACGGAAAAAATGGAGGACGTTCAAGGTAGTTTATTGTTGGCTAG...

蛋白

下载蛋白 FASTA

996 aa · LXL04_003014|LXL04_003014|OH1004|PROTEIN

MALDSVRLAGGKKTLEAGGFVLLVGGDASLNKGDRKRLKNTLGMIWVKVDVREKVEMIPKKTLLLLLERIKGTEKMEDVQGSLLLASGENSNVCKHCGNGGSNRDDFGRGRGRGRGSGKSRDGERFQRDKSHVKCFKCGEFGHYSNECPKWEKQEANLIEDESTTLDVTEVEVGCPEKVENQVRSSAGLRIPEGEIKLKFSTLTKCSKFETSEMVARFLGSTPLLPESWKLCARSNVMAPQGFLTDEVGGVTYVAFSGVQ...

上下游序列下载

序列方向与下载说明

上游/下游最大各 10000 bp。负链基因会自动反向互补，使最终 FASTA 为转录方向 5′→3′。

多版本 ID 对照

输入 ID	`LXL04_003014`
版本	OH-1004 / GCA_047496595.1_OSU_TarKok_2.0

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SNP / Indel 变异与样本携带情况CRA009020 · OH-1004

展开后加载该基因的变异记录。

基因基本信息与功能注释

基因 ID LXL04_003014

位置 Chr01:64987114-64995744 (+)

描述 Similar to PAD4: Lipase-like PAD4

拟南芥 / 水稻参考基因与文献

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拟南芥

参考基因 ID	可能功能	对应论文 / DOI
`At3g52430`	可能需要 MPK4 下游的脂肪酶来积累植物防御增强分子水杨酸，从而有助于植物针对侵入性生物营养病原体的先天免疫，并有助于识别微生物相关分子模式后的防御机制。	Arabidopsis thaliana PAD4 encodes a lipase-like gene that is important for salicylic acid signaling.1999 · DOI: 10.1073/pnas.96.23.13583 Arabidopsis thaliana EDS4 contributes to salicylic acid (SA)-dependent expression of defense responses: evidence for inhibition of jasmonic acid signaling by SA.2000 · DOI: 10.1094/mpmi.2000.13.5.503 Fumonisin B1-induced cell death in arabidopsis protoplasts requires jasmonate-, ethylene-, and salicylate-dependent signaling pathways.2000 · DOI: 10.1105/tpc.12.10.1823 Direct interaction between the Arabidopsis disease resistance signaling proteins, EDS1 and PAD4.2001 · DOI: 10.1093/emboj/20.19.5400 The disease resistance signaling components EDS1 and PAD4 are essential regulators of the cell death pathway controlled by LSD1 in Arabidopsis.2001 · DOI: 10.1105/tpc.010085 EDS5, an essential component of salicylic acid-dependent signaling for disease resistance in Arabidopsis, is a member of the MATE transporter family.2002 · DOI: 10.1105/tpc.010376 Arabidopsis RPP4 is a member of the RPP5 multigene family of TIR-NB-LRR genes and confers downy mildew resistance through multiple signalling components.2002 · DOI: 10.1046/j.0960-7412.2001.01229.x Genetic evidence that expression of NahG modifies defence pathways independent of salicylic acid biosynthesis in the Arabidopsis-Pseudomonas syringae pv. tomato interaction.2003 · DOI: 10.1046/j.1365-313x.2003.01881.x LESION SIMULATING DISEASE 1 is required for acclimation to conditions that promote excess excitation energy.2004 · DOI: 10.1104/pp.104.043646 A key role for ALD1 in activation of local and systemic defenses in Arabidopsis.2004 · DOI: 10.1111/j.1365-313x.2004.02200.x The atypical resistance gene, RPW8, recruits components of basal defence for powdery mildew resistance in Arabidopsis.2005 · DOI: 10.1111/j.1365-313x.2005.02356.x Arabidopsis SENESCENCE-ASSOCIATED GENE101 stabilizes and signals within an ENHANCED DISEASE SUSCEPTIBILITY1 complex in plant innate immunity.2005 · DOI: 10.1105/tpc.105.033910 Premature leaf senescence modulated by the Arabidopsis PHYTOALEXIN DEFICIENT4 gene is associated with defense against the phloem-feeding green peach aphid.2005 · DOI: 10.1104/pp.105.070433 Genetic analysis of developmentally regulated resistance to downy mildew (Hyaloperonospora parasitica) in Arabidopsis thaliana.2005 · DOI: 10.1094/mpmi-18-1226 Arabidopsis MAP kinase 4 regulates salicylic acid- and jasmonic acid/ethylene-dependent responses via EDS1 and PAD4.2006 · DOI: 10.1111/j.1365-313x.2006.02806.x Plastidial fatty acid levels regulate resistance gene-dependent defense signaling in Arabidopsis.2007 · DOI: 10.1073/pnas.0609259104 Phloem-based resistance to green peach aphid is controlled by Arabidopsis PHYTOALEXIN DEFICIENT4 without its signaling partner ENHANCED DISEASE SUSCEPTIBILITY1.2007 · DOI: 10.1111/j.1365-313x.2007.03241.x Lysigenous aerenchyma formation in Arabidopsis is controlled by LESION SIMULATING DISEASE1.2007 · DOI: 10.1105/tpc.106.048843 Arabidopsis proteins important for modulating defense responses to Pseudomonas syringae that secrete HopW1-1.2008 · DOI: 10.1111/j.1365-313x.2008.03439.x PAD4-dependent antibiosis contributes to the ssi2-conferred hyper-resistance to the green peach aphid.2010 · DOI: 10.1094/mpmi-23-5-0618 Different roles of Enhanced Disease Susceptibility1 (EDS1) bound to and dissociated from Phytoalexin Deficient4 (PAD4) in Arabidopsis immunity.2011 · DOI: 10.1111/j.1469-8137.2011.03675.x SAG101 forms a ternary complex with EDS1 and PAD4 and is required for resistance signaling against turnip crinkle virus.2011 · DOI: 10.1371/journal.ppat.1002318 Discrimination of Arabidopsis PAD4 activities in defense against green peach aphid and pathogens.2012 · DOI: 10.1104/pp.112.193417 Natural variation in small molecule-induced TIR-NB-LRR signaling induces root growth arrest via EDS1- and PAD4-complexed R protein VICTR in Arabidopsis.2012 · DOI: 10.1105/tpc.112.107235 Lesion simulating disease1, enhanced disease susceptibility1, and phytoalexin deficient4 conditionally regulate cellular signaling homeostasis, photosynthesis, water use efficiency, and seed yield in Arabidopsis.2013 · DOI: 10.1104/pp.112.208116 Isolation of Arabidopsis mutants with enhanced disease susceptibility by direct screening.1996 · DOI: 10.1093/genetics/143.2.973 Phytoalexin-deficient mutants of Arabidopsis reveal that PAD4 encodes a regulatory factor and that four PAD genes contribute to downy mildew resistance.1997 · DOI: 10.1093/genetics/146.1.381 PAD4 functions upstream from salicylic acid to control defense responses in Arabidopsis.1998 · DOI: 10.1105/tpc.10.6.1021 Correlation of defense gene induction defects with powdery mildew susceptibility in Arabidopsis enhanced disease susceptibility mutants.1998 · DOI: 10.1046/j.1365-313x.1998.00319.x
`At3g48080`	作为 EDS1 的第二个功能性拷贝。	暂无已核实直接文献
`UniProt: Q9XF23`	TIR-NB-LRR抗性蛋白特异介导的基础抗性和效应器触发免疫的正调控因子。	暂无已核实直接文献
`At3g48090`	是由 TIR-NB-LRR (TNL) 抗性蛋白特异介导的基础抗性和效应触发免疫的正调节因子。	EDS1, an essential component of R gene-mediated disease resistance in Arabidopsis has homology to eukaryotic lipases.1999 · DOI: 10.1073/pnas.96.6.3292 Direct interaction between the Arabidopsis disease resistance signaling proteins, EDS1 and PAD4.2001 · DOI: 10.1093/emboj/20.19.5400 Arabidopsis SENESCENCE-ASSOCIATED GENE101 stabilizes and signals within an ENHANCED DISEASE SUSCEPTIBILITY1 complex in plant innate immunity.2005 · DOI: 10.1105/tpc.105.033910 Balanced nuclear and cytoplasmic activities of EDS1 are required for a complete plant innate immune response.2010 · DOI: 10.1371/journal.ppat.1000970 Different roles of Enhanced Disease Susceptibility1 (EDS1) bound to and dissociated from Phytoalexin Deficient4 (PAD4) in Arabidopsis immunity.2011 · DOI: 10.1111/j.1469-8137.2011.03675.x Pathogen effectors target Arabidopsis EDS1 and alter its interactions with immune regulators.2011 · DOI: 10.1126/science.1211592 EDS1 contributes to nonhost resistance of Arabidopsis thaliana against Erwinia amylovora.2012 · DOI: 10.1094/mpmi-05-11-0111 Contrasting Roles of the Apoplastic Aspartyl Protease APOPLASTIC, ENHANCED DISEASE SUSCEPTIBILITY1-DEPENDENT1 and LEGUME LECTIN-LIKE PROTEIN1 in Arabidopsis Systemic Acquired Resistance.2014 · DOI: 10.1104/pp.114.239665
`At5g14930`	酰基水解酶触发叶片衰老。	Different roles of Enhanced Disease Susceptibility1 (EDS1) bound to and dissociated from Phytoalexin Deficient4 (PAD4) in Arabidopsis immunity.2011 · DOI: 10.1111/j.1469-8137.2011.03675.x SAG101 forms a ternary complex with EDS1 and PAD4 and is required for resistance signaling against turnip crinkle virus.2011 · DOI: 10.1371/journal.ppat.1002318

水稻

当前来源表未检出该物种的同源命中。

功能注释来源

查看注释来源

功能注释来源：OH1004 · LXL04_003014 · GCA_047496595.1_OSU_TarKok_2.0。

GO 注释（OH1004 来源）

GO:0000304 response to singlet oxygen 生物过程

GO:0001666 response to hypoxia 生物过程

GO:0002213 defense response to insect 生物过程

GO:0006629 lipid metabolic process 生物过程

GO:0006952 defense response 生物过程

GO:0009617 response to bacterium 生物过程

GO:0009625 response to insect 生物过程

GO:0009626 plant-type hypersensitive response 生物过程

GO:0009627 systemic acquired resistance 生物过程

GO:0009751 response to salicylic acid 生物过程

GO:0009862 systemic acquired resistance, salicylic acid mediated signaling pathway 生物过程

GO:0009873 ethylene-activated signaling pathway 生物过程

KEGG 基因交叉引用

ath:AT3G48080

ath:AT3G48090

ath:AT3G52430

以下为同源蛋白关联的 KEGG 基因编号，不代表本基因已获得通路功能验证。

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基因表达

查看该基因在不同研究、组织与处理条件下的表达量。表达结果按研究与计量单位分别展示。

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数据来源与对应关系说明

表达数据来自公开转录组研究；参考版本、样本信息和表达单位见查询结果。跨参考版本的对应关系不唯一时，不自动选择表达记录；缺失值不视为表达量为零。

亚细胞定位 Top 5

以下为计算预测或同源注释，不能替代定位实验。

细胞核0.495

排名 1 · LXL04_003014 · OH-1004

细胞质0.396

排名 2 · LXL04_003014 · OH-1004

细胞膜0.101

排名 3 · LXL04_003014 · OH-1004

内质网0.064

排名 4 · LXL04_003014 · OH-1004

高尔基体0.044

排名 5 · LXL04_003014 · OH-1004

LocPro · 直接预测 · 计算预测，非定位实验结果

进入亚细胞定位查询

预测功能结构域

结构域结果来自 Pfam-A/HMMER；位置为对应蛋白序列上的氨基酸坐标。

PF00098.29zf-CCHC134-150 aa

PF01764.32Lipase_3308-413 aa

PF18117.7EDS1_EP605-813 aa

PF13966.12zf-RVT856-894 aa

基因 ID	结构域编号	结构域名称	起始 aa	终止 aa	E 值	评分
LXL04_003014	`PF00098.29`	zf-CCHC	134	150	4.6e-06	27.2
LXL04_003014	`PF01764.32`	Lipase_3	308	413	1.9e-18	67.4
LXL04_003014	`PF18117.7`	EDS1_EP	605	813	2.2e-71	240.6
LXL04_003014	`PF13966.12`	zf-RVT	856	894	7.9e-06	27.2

拟南芥 / 水稻蛋白同源

仅展示拟南芥和水稻；Swiss-Prot 为人工审校条目，TrEMBL 为补充序列候选。同源相似性不等同于实验验证。

下载当前结果

蛋白	物种	描述	一致性	数据库	置信等级
`Q9S745`	拟南芥	Lipase-like PAD4	42.416%	Swiss-Prot	低置信数据库同源证据
`Q9SU71`	拟南芥	Protein EDS1B	26.199%	Swiss-Prot	低置信数据库同源证据
`Q9XF23`	拟南芥	Protein EDS1L	26.978%	Swiss-Prot	低置信数据库同源证据
`Q9SU72`	拟南芥	Protein EDS1	27.439%	Swiss-Prot	低置信数据库同源证据
`Q4F883`	拟南芥	Senescence-associated carboxylesterase 101	27.457%	Swiss-Prot	低置信数据库同源证据

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