TkA08G048640 | RubberDandelionOmics

Gene overview

TkA08G048640

Reference: TK1151 Chr: Chr08 Coordinates: 12368810-12372500 Strand: - Type: protein_coding

cDNA / CDS / Protein Sequences

Available sequence downloads CDS FASTA Protein FASTA cDNA FASTA

cDNA

2609 bp · TkA08G048640|TK1151|cDNA

AACATTTGTAAAAAATAAAAATGATAAAAGATTCAATTTGATGTGCAGAATGAACGACAAATTCTGTATTTGATTCCGTACTTGGGCGCATATACCAAAAGGCCACGTTAGCCGCCATGGTATAGTGTACTCGTTTCCTTTCCCTGTCATTGGAAGAGCGCAACAGAAACCATTCCCCATTTGCCATTCCCGGTGATGATCCATTGATCCTTTTATTCCGAATACTCCTTTCTCTTTCAAATTCCATCAGAATCACATAA...

CDS

Download CDS FASTA

1899 bp · TkA08G048640|TK1151|CDS

ATGATGACTCAACAAGGAGGAGAGATAATCCACGATGATCCTGCACTCAAGGAACACATATACACTTCTTACAAGGAACTCAAAGATGGCCATGTTAGTGTCAACTTCATAGAAAACATTCTCAAATGTCCTTACTGTCCCGATAGCAGAGAATACACTTACACAGACCTCTGCAGACATGTCACAAGAATCATAAAGGAGTCAAAAAGCTCAACTTTAAAAGACAAAGCCAAACACATGGGACTAGAAGAGTTTCTACA...

Protein

Download Protein FASTA

632 aa · TkA08G048640|TK1151|PROTEIN

MMTQQGGEIIHDDPALKEHIYTSYKELKDGHVSVNFIENILKCPYCPDSREYTYTDLCRHVTRIIKESKSSTLKDKAKHMGLEEFLHRDFDPKITNSKPKTTDSNQMNGDMSRHKNRELEEPVVWPWMVVIANIPVQYKDGRYTGDSGKKLKDEWTKEGYNPTKVHPLWSWRGHSGFAIVEFGKEWSGFGDAMKFVKKFEVSKHGRKDWYDGRRGKDDDLYAWIARDEDYNCNSLVGDYLRKNGDLKTVAEKQKEDQVKD...

Flanking Sequence Download

Sequence orientation and download details

Upstream/downstream are capped at 10000 bp per side. Negative-strand genes are reverse-complemented so the final FASTA follows transcriptional 5′→3′ orientation.

ID Mapping

Input ID	`TkA08G048640`
TK1151 ID	TkA08G048640
OH-1004 ID	LXL04_017817
Relationship / confidence	Rbh High Identity Coverage Synteny / Strict
Protein identity (%)	97.900
Protein coverage (%)	TK1151 100.000 / OH-1004 100.000 Coverage and evidence Coverage is the aligned span of the best-scoring HSP divided by representative protein length. A homolog match does not establish functional validation.
Source version	TK1151 / GWHBCHF00000000

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SNP / Indel variants and carrier samplesCRA009020 · TK1151

Expand to load variant records for this gene.

Basic Information and Functional Annotation

Gene ID TkA08G048640

Location Chr08:12368810-12372500 (-)

Description Similar to IDN2: Protein INVOLVED IN DE NOVO 2

Arabidopsis / Rice Reference Genes and Papers

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Arabidopsis

Reference gene ID	Possible function	Papers / DOI
`At3g48670`	Forms a complex with FDM1/IDNL1 and FDM2/IDNL2 that is required for RNA-directed DNA methylation (RdDM) and that functions at a downstream step of the RdDM pathway and downstream of small interfering RNA (siRNA) formation.	IDN1 and IDN2 are required for de novo DNA methylation in Arabidopsis thaliana.2009 · DOI: 10.1038/nsmb.1690 An SGS3-like protein functions in RNA-directed DNA methylation and transcriptional gene silencing in Arabidopsis.2010 · DOI: 10.1111/j.1365-313x.2010.04130.x IDN2 and its paralogs form a complex required for RNA-directed DNA methylation.2012 · DOI: 10.1371/journal.pgen.1002693 INVOLVED IN DE NOVO 2-containing complex involved in RNA-directed DNA methylation in Arabidopsis.2012 · DOI: 10.1073/pnas.1206638109 IDN2 has a role downstream of siRNA formation in RNA-directed DNA methylation.2012 · DOI: 10.4161/epi.21237 A SWI/SNF chromatin-remodeling complex acts in noncoding RNA-mediated transcriptional silencing.2013 · DOI: 10.1016/j.molcel.2012.11.011 RNA-directed DNA methylation requires stepwise binding of silencing factors to long non-coding RNA.2014 · DOI: 10.1111/tpj.12563 Two Components of the RNA-Directed DNA Methylation Pathway Associate with MORC6 and Silence Loci Targeted by MORC6 in Arabidopsis.2016 · DOI: 10.1371/journal.pgen.1006026
`At3g12550`	Acts in association with FDM4 and FDM5 for RNA-directed DNA methylation (RdDM).	A subgroup of SGS3-like proteins act redundantly in RNA-directed DNA methylation.2012 · DOI: 10.1093/nar/gks034
`At1g13790`	Acts in association with FDM3 and FDM5 for RNA-directed DNA methylation (RdDM).	A subgroup of SGS3-like proteins act redundantly in RNA-directed DNA methylation.2012 · DOI: 10.1093/nar/gks034
`At1g80790`	Acts in association with FDM3 and FDM4 for RNA-directed DNA methylation (RdDM).	A subgroup of SGS3-like proteins act redundantly in RNA-directed DNA methylation.2012 · DOI: 10.1093/nar/gks034
`At1g15910`	Forms a complex with IDN2 and FDM2/IDNL2 that is required for RNA-directed DNA methylation (RdDM) and that functions at a downstream step of the RdDM pathway.	A subgroup of SGS3-like proteins act redundantly in RNA-directed DNA methylation.2012 · DOI: 10.1093/nar/gks034 IDN2 and its paralogs form a complex required for RNA-directed DNA methylation.2012 · DOI: 10.1371/journal.pgen.1002693 INVOLVED IN DE NOVO 2-containing complex involved in RNA-directed DNA methylation in Arabidopsis.2012 · DOI: 10.1073/pnas.1206638109

Rice

No hit for this species in the current source table.

Functional annotation source

View annotation sources

Functional annotation source: OH1004 · LXL04_017817 · GCA_047496595.1_OSU_TarKok_2.0. These OH1004 annotations are retrieved through ID mapping; the Arabidopsis/rice table below uses protein alignments from the query reference.

GO annotations (OH1004 source)

GO:0010569 regulation of double-strand break repair via homologous recombination Biological Process

GO:0032259 methylation Biological Process

GO:0046686 response to cadmium ion Biological Process

GO:0080188 gene silencing by siRNA-directed DNA methylation Biological Process

GO:0005634 nucleus Cellular Component

GO:0005737 cytoplasm Cellular Component

GO:0009506 plasmodesma Cellular Component

GO:0003677 DNA binding Molecular Function

GO:0003723 RNA binding Molecular Function

GO:0003725 double-stranded RNA binding Molecular Function

GO:0008168 methyltransferase activity Molecular Function

KEGG gene cross-reference

ath:AT1G13790

ath:AT1G15910

ath:AT3G12550

ath:AT3G48670

These KEGG gene identifiers are linked through homologous proteins; they do not establish pathway function for this gene.

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Gene expression

View expression in different studies, tissues and treatments. Results are presented separately by study and measurement unit.

View expression for this gene

Data sources and gene correspondence

Expression data come from public transcriptome studies. Reference genomes, sample metadata and measurement units are shown with the results. Ambiguous cross-reference correspondences do not select an expression record automatically; missing values do not mean zero expression.

Subcellular Localization Top 5

Computational predictions or homology annotations below do not replace localization experiments.

Cytoplasm0.591

Rank 1 · TkA08G048640 · TK1151

Nucleus0.429

Rank 2 · TkA08G048640 · TK1151

Cell membrane0.076

Rank 3 · TkA08G048640 · TK1151

Endoplasmic reticulum0.044

Rank 4 · TkA08G048640 · TK1151

Mitochondrion0.020

Rank 5 · TkA08G048640 · TK1151

LocPro · Direct prediction · Computational prediction, not experimental localization

Open Subcellular Module

Predicted Functional Domains

Domain results are from Pfam-A/HMMER; positions are amino-acid coordinates on the protein sequence.

PF21829DUF688923-33 aa

PF05605zf-Di1941-62 aa

PF03470zf-XS43-82 aa

PF03468XS121-231 aa

PF16045LisH_2232-244 aa

PF03469XH310-310 aa

PF03468XS331-376 aa

PF03469XH444-460 aa

Gene ID	Domain ID	Domain Name	Start aa	End aa	E-value	Score
TkA08G048640	`PF21829`	DUF6889	23	33	0.21	12.0
TkA08G048640	`PF05605`	zf-Di19	41	62	0.034	15.1
TkA08G048640	`PF03470`	zf-XS	43	82	1.8e-05	25.7
TkA08G048640	`PF03468`	XS	121	231	2e-37	128.7
TkA08G048640	`PF16045`	LisH_2	232	244	0.24	11.2
TkA08G048640	`PF03469`	XH	310	310	7.3e-48	162.6
TkA08G048640	`PF03468`	XS	331	376	2e-37	128.7
TkA08G048640	`PF03469`	XH	444	460	7.3e-48	162.6
TkA08G048640	`PF21829`	DUF6889	456	472	0.21	12.0
TkA08G048640	`PF03469`	XH	501	629	7.3e-48	162.6

Arabidopsis / Rice Protein Homology

Only Arabidopsis and rice are shown. Swiss-Prot entries are reviewed; TrEMBL entries are supplementary sequence candidates. Similarity is not experimental validation.

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Protein	Organism	Description	Identity	Database	Confidence
`Q8VZ79`	Arabidopsis thaliana	sp\|Q8VZ79\|IDN2_ARATH Protein INVOLVED IN DE NOVO 2	40.800%	Swiss-Prot	Medium
`Q9LHB1`	Arabidopsis thaliana	sp\|Q9LHB1\|FDM3_ARATH Factor of DNA methylation 3	38.600%	Swiss-Prot	Medium
`Q9LMH6`	Arabidopsis thaliana	sp\|Q9LMH6\|FDM4_ARATH Factor of DNA methylation 4	43.700%	Swiss-Prot	Medium
`Q9SAI1`	Arabidopsis thaliana	sp\|Q9SAI1\|FDM5_ARATH Factor of DNA methylation 5	35.100%	Swiss-Prot	Medium
`Q9S9P3`	Arabidopsis thaliana	sp\|Q9S9P3\|FDM1_ARATH Factor of DNA methylation 1	33.600%	Swiss-Prot	Medium

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