LXL04_028554 | RubberDandelionOmics

基因概览

LXL04_028554

当前版本: OH-1004 染色体: Chr06 坐标: 45554420-45557153 链方向: + 类型: protein_coding

cDNA / CDS / 蛋白序列

可用序列下载 CDS FASTA 蛋白 FASTA cDNA FASTA

cDNA

1404 bp · LXL04_028554|LXL04_028554|OH1004|cDNA

ATGGAGGAGATGCTTCCGTCGGTGCCATTAAGCGTACGTAATCCAATCTGTAGCAAAACCCTCGTAGTAATCACTGGGATACAACAACAACAGCAATTCATGGCGGATAAAATCAATTTCGACGATTGTAACAATCATTCACAAGATTTGAATTCGGATTCTGGGTTTCAAGAAAGCGAGGATGAATTGATGTCATTAGAAGGCGATCCTGATCGCATCTTTGAAACCTCATGTACGCTATCTGTAGTGAGCGATTCAAG...

CDS

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1404 bp · LXL04_028554|LXL04_028554|OH1004|CDS

ATGGAGGAGATGCTTCCGTCGGTGCCATTAAGCGTACGTAATCCAATCTGTAGCAAAACCCTCGTAGTAATCACTGGGATACAACAACAACAGCAATTCATGGCGGATAAAATCAATTTCGACGATTGTAACAATCATTCACAAGATTTGAATTCGGATTCTGGGTTTCAAGAAAGCGAGGATGAATTGATGTCATTAGAAGGCGATCCTGATCGCATCTTTGAAACCTCATGTACGCTATCTGTAGTGAGCGATTCAAG...

蛋白

下载蛋白 FASTA

467 aa · LXL04_028554|LXL04_028554|OH1004|PROTEIN

MEEMLPSVPLSVRNPICSKTLVVITGIQQQQQFMADKINFDDCNNHSQDLNSDSGFQESEDELMSLEGDPDRIFETSCTLSVVSDSSSLCNEDFIAFESLNTLQEDGEKGVCLGDVATTGIVDDVATTEIVVSEKVSSVSRSVFEVDCVALWGFTSICGRRPEMEDAVATVPRFLKIPVQMLTGDKMTKSLSHLTAHFFGVYDGHGGSQVANYCSGRVHTALQEELEPLMAAGGGDESTTNNENSCQDLWKKAFIRCFLR...

上下游序列下载

序列方向与下载说明

上游/下游最大各 10000 bp。负链基因会自动反向互补，使最终 FASTA 为转录方向 5′→3′。

多版本 ID 对照

输入 ID	`LXL04_028554`
版本	OH-1004 / GCA_047496595.1_OSU_TarKok_2.0

查看完整 ID 对照表

SNP / Indel 变异与样本携带情况CRA009020 · OH-1004

展开后加载该基因的变异记录。

基因基本信息与功能注释

基因 ID LXL04_028554

位置 Chr06:45554420-45557153 (+)

描述 Similar to HAB1: Protein phosphatase 2C 16

拟南芥 / 水稻参考基因与文献

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拟南芥

参考基因 ID	可能功能	对应论文 / DOI
`At1g72770`	脱落酸（ABA）信号通路的关键组成部分和抑制因子，调节多种ABA反应，如气孔关闭、种子萌发和营养生长抑制。	Gain-of-function and loss-of-function phenotypes of the protein phosphatase 2C HAB1 reveal its role as a negative regulator of abscisic acid signalling.2004 · DOI: 10.1046/j.1365-313x.2003.01966.x Enhancement of abscisic acid sensitivity and reduction of water consumption in Arabidopsis by combined inactivation of the protein phosphatases type 2C ABI1 and HAB1.2006 · DOI: 10.1104/pp.106.081018 A hypermorphic mutation in the protein phosphatase 2C HAB1 strongly affects ABA signaling in Arabidopsis.2006 · DOI: 10.1016/j.febslet.2006.07.047
`At1g17550`	脱落酸（ABA）信号通路的关键组成部分和抑制因子，调节多种ABA反应，如气孔关闭、种子萌发和营养生长抑制。	暂无已核实直接文献
`At4g26080`	脱落酸（ABA）信号通路的关键组分和抑制因子，调控众多ABA反应，如气孔关闭、质膜渗透水性（Pos）、干旱诱导的抗性和根形成、对葡萄糖的响应、高光胁迫、种子发芽以及营养生长抑制。	Arabidopsis abi1-1 and abi2-1 phosphatase mutations reduce abscisic acid-induced cytoplasmic calcium rises in guard cells.1999 · DOI: 10.1105/tpc.11.9.1785 ABI1 protein phosphatase 2C is a negative regulator of abscisic acid signaling.1999 · DOI: 10.1105/tpc.11.10.1897 The role of ABI1 in abscisic acid signal transduction: from gene to cell.1998 · PMID: 10645425 The genes ABI1 and ABI2 are involved in abscisic acid- and drought-inducible expression of the Daucus carota L. Dc3 promoter in guard cells of transgenic Arabidopsis thaliana (L.) Heynh.2000 · DOI: 10.1007/s004250050692 Analysis of Arabidopsis glucose insensitive mutants, gin5 and gin6, reveals a central role of the plant hormone ABA in the regulation of plant vegetative development by sugar.2000 · PMID: 10950871 The ABI1 and ABI2 protein phosphatases 2C act in a negative feedback regulatory loop of the abscisic acid signalling pathway.2001 · DOI: 10.1046/j.1365-313x.2001.00965.x Cortical actin filaments in guard cells respond differently to abscisic acid in wild-type and abi1-1 mutant Arabidopsis.2001 · DOI: 10.1007/s004250000489 Dissection of abscisic acid signal transduction pathways in barley aleurone layers.2001 · DOI: 10.1023/a:1011667312754 Abscisic acid activation of plasma membrane Ca(2+) channels in guard cells requires cytosolic NAD(P)H and is differentially disrupted upstream and downstream of reactive oxygen species production in abi1-1 and abi2-1 protein phosphatase 2C mutants.2001 · DOI: 10.1105/tpc.010210 The role of ABA and the transpiration stream in the regulation of the osmotic water permeability of leaf cells.2001 · DOI: 10.1073/pnas.231471998 Use of infrared thermal imaging to isolate Arabidopsis mutants defective in stomatal regulation.2002 · DOI: 10.1046/j.1365-313x.2002.01322.x Homeodomain protein ATHB6 is a target of the protein phosphatase ABI1 and regulates hormone responses in Arabidopsis.2002 · DOI: 10.1093/emboj/cdf316 A calcium sensor and its interacting protein kinase are global regulators of abscisic acid signaling in Arabidopsis.2002 · DOI: 10.1016/s1534-5807(02)00229-0 Role of Abscisic Acid in Drought-Induced Freezing Tolerance, Cold Acclimation, and Accumulation of LT178 and RAB18 Proteins in Arabidopsis thaliana.1995 · DOI: 10.1104/pp.107.1.141 Drought Rhizogenesis in Arabidopsis thaliana (Differential Responses of Hormonal Mutants).1994 · DOI: 10.1104/pp.104.2.761 Maternal Effects Govern Variable Dominance of Two Abscisic Acid Response Mutations in Arabidopsis thaliana.1994 · DOI: 10.1104/pp.105.4.1203 Genome-wide gene expression profiling in Arabidopsis thaliana reveals new targets of abscisic acid and largely impaired gene regulation in the abi1-1 mutant.2002 · DOI: 10.1242/jcs.00175 Control of Ascorbate Peroxidase 2 expression by hydrogen peroxide and leaf water status during excess light stress reveals a functional organisation of Arabidopsis leaves.2003 · DOI: 10.1046/j.1365-313x.2003.01656.x The abi1-1 mutation blocks ABA signaling downstream of cADPR action.2003 · DOI: 10.1046/j.1365-313x.2003.01721.x Synthesis of the Arabidopsis bifunctional lysine-ketoglutarate reductase/saccharopine dehydrogenase enzyme of lysine catabolism is concertedly regulated by metabolic and stress-associated signals.2003 · DOI: 10.1104/pp.103.026294 Regulation of the ABA-sensitive Arabidopsis potassium channel gene GORK in response to water stress.2003 · DOI: 10.1016/s0014-5793(03)01118-9 Phospholipase D alpha 1-derived phosphatidic acid interacts with ABI1 phosphatase 2C and regulates abscisic acid signaling.2004 · DOI: 10.1073/pnas.0402112101 Generation of active pools of abscisic acid revealed by in vivo imaging of water-stressed Arabidopsis.2005 · DOI: 10.1104/pp.104.053082 Heat stress phenotypes of Arabidopsis mutants implicate multiple signaling pathways in the acquisition of thermotolerance.2005 · DOI: 10.1104/pp.105.062257 Role of abscisic acid (ABA) and Arabidopsis thaliana ABA-insensitive loci in low water potential-induced ABA and proline accumulation.2006 · DOI: 10.1093/jxb/erj026 The regulatory domain of SRK2E/OST1/SnRK2.6 interacts with ABI1 and integrates abscisic acid (ABA) and osmotic stress signals controlling stomatal closure in Arabidopsis.2006 · DOI: 10.1074/jbc.m509820200 Fibrillin expression is regulated by abscisic acid response regulators and is involved in abscisic acid-mediated photoprotection.2006 · DOI: 10.1073/pnas.0501720103 A bifurcating pathway directs abscisic acid effects on stomatal closure and opening in Arabidopsis.2006 · DOI: 10.1126/science.1123769 Abscisic Acid Elicits the Water-Stress Response in Root Hairs of Arabidopsis thaliana.1992 · DOI: 10.1104/pp.100.1.216 Enhancement of abscisic acid sensitivity and reduction of water consumption in Arabidopsis by combined inactivation of the protein phosphatases type 2C ABI1 and HAB1.2006 · DOI: 10.1104/pp.106.081018 Abscisic acid antagonizes ethylene-induced hyponastic growth in Arabidopsis.2007 · DOI: 10.1104/pp.106.092700 Pseudomonas syringae pv. tomato hijacks the Arabidopsis abscisic acid signalling pathway to cause disease.2007 · DOI: 10.1038/sj.emboj.7601575 Nuclear localization of the mutant protein phosphatase abi1 is required for insensitivity towards ABA responses in Arabidopsis.2008 · DOI: 10.1111/j.1365-313x.2008.03454.x Cold acclimation and cold-regulated gene expression in ABA mutants of Arabidopsis thaliana.1991 · DOI: 10.1007/bf00028738 ABI1 and PP2CA phosphatases are negative regulators of Snf1-related protein kinase1 signaling in Arabidopsis.2013 · DOI: 10.1105/tpc.113.114066 Arabidopsis ABA-Activated Kinase MAPKKK18 is Regulated by Protein Phosphatase 2C ABI1 and the Ubiquitin-Proteasome Pathway.2015 · DOI: 10.1093/pcp/pcv146 AIK1, A Mitogen-Activated Protein Kinase, Modulates Abscisic Acid Responses through the MKK5-MPK6 Kinase Cascade.2017 · DOI: 10.1104/pp.16.01386 Sensitivity to abscisic acid of guard-cell K+ channels is suppressed by abi1-1, a mutant Arabidopsis gene encoding a putative protein phosphatase.1995 · DOI: 10.1073/pnas.92.21.9520 Abscisic acid-insensitive mutations provide evidence for stage-specific signal pathways regulating expression of an Arabidopsis late embryogenesis-abundant (lea) gene.1993 · DOI: 10.1007/bf00291999 The Arabidopsis homeobox gene ATHB-7 is induced by water deficit and by abscisic acid.1996 · DOI: 10.1046/j.1365-313x.1996.10020375.x Protein phosphatase activity of abscisic acid insensitive 1 (ABI1) protein from Arabidopsis thaliana.1996 · DOI: 10.1111/j.1432-1033.1996.0193t.x Differential abscisic acid regulation of guard cell slow anion channels in Arabidopsis wild-type and abi1 and abi2 mutants.1997 · DOI: 10.1105/tpc.9.3.409 Abscisic acid-independent and abscisic acid-dependent regulation of proline biosynthesis following cold and osmotic stresses in Arabidopsis thaliana.1997 · DOI: 10.1007/s004380050397 Interactions between the ABI1 and the ectopically expressed ABI3 genes in controlling abscisic acid responses in Arabidopsis vegetative tissues.1997 · DOI: 10.1046/j.1365-313x.1997.11040693.x The Arabidopsis ABSCISIC ACID-INSENSITIVE2 (ABI2) and ABI1 genes encode homologous protein phosphatases 2C involved in abscisic acid signal transduction.1997 · DOI: 10.1105/tpc.9.5.759 Alteration of anion channel kinetics in wild-type and abi1-1 transgenic Nicotiana benthamiana guard cells by abscisic acid.1997 · DOI: 10.1046/j.1365-313x.1997.12010203.x Convergence of the abscisic acid, CO2, and extracellular calcium signal transduction pathways in stomatal guard cells.1997 · DOI: 10.1104/pp.114.4.1557 Differential expression of two P5CS genes controlling proline accumulation during salt-stress requires ABA and is regulated by ABA1, ABI1 and AXR2 in Arabidopsis.1997 · DOI: 10.1046/j.1365-313x.1997.00557.x Mutational analysis of protein phosphatase 2C involved in abscisic acid signal transduction in higher plants.1998 · DOI: 10.1073/pnas.95.3.975

水稻

参考基因 ID	可能功能	对应论文 / DOI
`Os01g0583100`	可能的蛋白磷酸酶，可能在脱落酸（ABA）信号中发挥作用。	暂无已核实直接文献
`Os05g0592800`	蛋白磷酸酶，作为脱落酸(ABA)信号的负调控因子。	ABA Regulates Subcellular Redistribution of OsABI-LIKE2, a Negative Regulator in ABA Signaling, to Control Root Architecture and Drought Resistance in Oryza sativa.2015 · DOI: 10.1093/pcp/pcv154

功能注释来源

查看注释来源

功能注释来源：OH1004 · LXL04_028554 · GCA_047496595.1_OSU_TarKok_2.0。

GO 注释（OH1004 来源）

GO:0006470 protein dephosphorylation 生物过程

GO:0009408 response to heat 生物过程

GO:0009409 response to cold 生物过程

GO:0009414 response to water deprivation 生物过程

GO:0009737 response to abscisic acid 生物过程

GO:0009738 abscisic acid-activated signaling pathway 生物过程

GO:0009787 regulation of abscisic acid-activated signaling pathway 生物过程

GO:0009788 negative regulation of abscisic acid-activated signaling pathway 生物过程

GO:0010119 regulation of stomatal movement 生物过程

GO:0048364 root development 生物过程

GO:1902531 regulation of intracellular signal transduction 生物过程

GO:0005634 nucleus 细胞组分

KEGG 基因交叉引用

ath:AT1G17550

ath:AT1G72770

ath:AT4G26080

dosa:Os01g0583100

dosa:Os05g0592800

osa:4339797

以下为同源蛋白关联的 KEGG 基因编号，不代表本基因已获得通路功能验证。

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基因表达

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数据来源与对应关系说明

表达数据来自公开转录组研究；参考版本、样本信息和表达单位见查询结果。跨参考版本的对应关系不唯一时，不自动选择表达记录；缺失值不视为表达量为零。

亚细胞定位 Top 5

以下为计算预测或同源注释，不能替代定位实验。

细胞核0.593

排名 1 · LXL04_028554 · OH-1004

细胞质0.392

排名 2 · LXL04_028554 · OH-1004

细胞膜0.117

排名 3 · LXL04_028554 · OH-1004

内质网0.052

排名 4 · LXL04_028554 · OH-1004

溶酶体／液泡0.041

排名 5 · LXL04_028554 · OH-1004

LocPro · 直接预测 · 计算预测，非定位实验结果

进入亚细胞定位查询

预测功能结构域

结构域结果来自 Pfam-A/HMMER；位置为对应蛋白序列上的氨基酸坐标。

PF00481.27PP2C181-450 aa

基因 ID	结构域编号	结构域名称	起始 aa	终止 aa	E 值	评分
LXL04_028554	`PF00481.27`	PP2C	181	450	1.5e-63	215.6

拟南芥 / 水稻蛋白同源

仅展示拟南芥和水稻；Swiss-Prot 为人工审校条目，TrEMBL 为补充序列候选。同源相似性不等同于实验验证。

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蛋白	物种	描述	一致性	数据库	置信等级
`Q9CAJ0`	拟南芥	Protein phosphatase 2C 16	52.224%	Swiss-Prot	强数据库同源证据
`Q9LNP9`	拟南芥	Protein phosphatase 2C 7	63.435%	Swiss-Prot	强数据库同源证据
`P49597`	拟南芥	Protein phosphatase 2C 56	53.125%	Swiss-Prot	强数据库同源证据
`Q0JLP9`	水稻	Probable protein phosphatase 2C 6	66.382%	Swiss-Prot	强数据库同源证据
`Q6L4R7`	水稻	Protein phosphatase 2C 53	60.354%	Swiss-Prot	强数据库同源证据

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