query	query_gene_id	query_protein_id	source_reference	hit_rank	swissprot_acc	swissprot_entry	database_section	target_gene_id	description	organism	homolog_gene_name	percent_identity	alignment_length	query_coverage	evalue	bitscore	confidence	evidence_type	source_db	reference_gene_id	reference_function_zh	reference_function_en	reference_papers_json
LXL04_005410	gene-LXL04_005410	KAL4592416.1	OH-1004	1	Q9C9U5	SIS8_ARATH	Swiss-Prot		Probable serine/threonine-protein kinase SIS8 OS=Arabidopsis thaliana OX=3702 GN=SIS8 PE=1 SV=1	Arabidopsis thaliana	SIS8	58.252	309	39.922	2.36e-111	365.0	weak_database_homology	BLASTP to reviewed UniProt Swiss-Prot	UniProt Swiss-Prot current_release 2026-06-10	At1g73660	作为耐盐负调节剂。	Acts as a negative regulator of salt tolerance.	"[{""pmid"":""18299802"",""title"":""The genetic locus At1g73660 encodes a putative MAPKKK and negatively regulates salt tolerance in Arabidopsis."",""doi"":""10.1007/s11103-008-9306-8"",""url"":""https://pubmed.ncbi.nlm.nih.gov/18299802/"",""year"":""2008"",""journal"":""Plant molecular biology"",""authors"":""Gao L, Xiang CB."",""matched_aliases"":[""At1g73660""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false},{""pmid"":""24320620"",""title"":""SIS8, a putative mitogen-activated protein kinase kinase kinase, regulates sugar-resistant seedling development in Arabidopsis."",""doi"":""10.1111/tpj.12404"",""url"":""https://pubmed.ncbi.nlm.nih.gov/24320620/"",""year"":""2014"",""journal"":""The Plant journal : for cell and molecular biology"",""authors"":""Huang Y, Li CY, Qi Y, Park S, Gibson SI."",""matched_aliases"":[""At1g73660"",""SIS8""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false}]"
LXL04_005410	gene-LXL04_005410	KAL4592416.1	OH-1004	2	Q9FPR3	EDR1_ARATH	Swiss-Prot		Serine/threonine-protein kinase EDR1 OS=Arabidopsis thaliana OX=3702 GN=EDR1 PE=1 SV=1	Arabidopsis thaliana	EDR1	57.565	271	35.013	6.5e-108	354.0	weak_database_homology	BLASTP to reviewed UniProt Swiss-Prot	UniProt Swiss-Prot current_release 2026-06-10	At1g08720	参与调控MAP激酶级联的MAPKKK丝氨酸/苏氨酸蛋白激酶；该级联可能包括MPK3和MPK6，负向调控水杨酸（SA）依赖的防御应答、脱落酸（ABA）信号及乙烯诱导的衰老。	MAPKKK serine/threonine-protein kinase involved in the regulation of a MAP kinase cascade (probably including MPK3 and MPK6) that negatively regulates salicylic acid- (SA-) dependent defense responses, abscisic acid (ABA) signaling, and ethylene-induced senescence.	"[{""pmid"":""11114160"",""title"":""Negative regulation of defense responses in plants by a conserved MAPKK kinase."",""doi"":""10.1073/pnas.98.1.373"",""url"":""https://pubmed.ncbi.nlm.nih.gov/11114160/"",""year"":""2001"",""journal"":""Proceedings of the National Academy of Sciences of the United States of America"",""authors"":""Frye CA, Tang D, Innes RW."",""matched_aliases"":[""EDR1""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false},{""pmid"":""12492839"",""title"":""Overexpression of a kinase-deficient form of the EDR1 gene enhances powdery mildew resistance and ethylene-induced senescence in Arabidopsis."",""doi"":""10.1046/j.1365-313x.2002.01482.x"",""url"":""https://pubmed.ncbi.nlm.nih.gov/12492839/"",""year"":""2002"",""journal"":""The Plant journal : for cell and molecular biology"",""authors"":""Tang D, Innes RW."",""matched_aliases"":[""EDR1""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false},{""pmid"":""15894742"",""title"":""Regulation of plant disease resistance, stress responses, cell death, and ethylene signaling in Arabidopsis by the EDR1 protein kinase."",""doi"":""10.1104/pp.105.060400"",""url"":""https://pubmed.ncbi.nlm.nih.gov/15894742/"",""year"":""2005"",""journal"":""Plant physiology"",""authors"":""Tang D, Christiansen KM, Innes RW."",""matched_aliases"":[""EDR1""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false},{""pmid"":""16565218"",""title"":""Costs and benefits of priming for defense in Arabidopsis."",""doi"":""10.1073/pnas.0510213103"",""url"":""https://pubmed.ncbi.nlm.nih.gov/16565218/"",""year"":""2006"",""journal"":""Proceedings of the National Academy of Sciences of the United States of America"",""authors"":""van Hulten M, Pelser M, van Loon LC, Pieterse CM, Ton J."",""matched_aliases"":[""EDR1""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false},{""pmid"":""18815384"",""title"":""Powdery mildew resistance conferred by loss of the ENHANCED DISEASE RESISTANCE1 protein kinase is suppressed by a missense mutation in KEEP ON GOING, a regulator of abscisic acid signaling."",""doi"":""10.1104/pp.108.127605"",""url"":""https://pubmed.ncbi.nlm.nih.gov/18815384/"",""year"":""2008"",""journal"":""Plant physiology"",""authors"":""Wawrzynska A, Christiansen KM, Lan Y, Rodibaugh NL, Innes RW."",""matched_aliases"":[""EDR1""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false},{""pmid"":""19318610"",""title"":""Mitogen-activated protein kinases 3 and 6 are required for full priming of stress responses in Arabidopsis thaliana."",""doi"":""10.1105/tpc.108.062158"",""url"":""https://pubmed.ncbi.nlm.nih.gov/19318610/"",""year"":""2009"",""journal"":""The Plant cell"",""authors"":""Beckers GJ, Jaskiewicz M, Liu Y, Underwood WR, He SY, Zhang S, Conrath U."",""matched_aliases"":[""EDR1""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false},{""pmid"":""21343429"",""title"":""The KEEP ON GOING protein of Arabidopsis recruits the ENHANCED DISEASE RESISTANCE1 protein to trans-Golgi network/early endosome vesicles."",""doi"":""10.1104/pp.110.171785"",""url"":""https://pubmed.ncbi.nlm.nih.gov/21343429/"",""year"":""2011"",""journal"":""Plant physiology"",""authors"":""Gu Y, Innes RW."",""matched_aliases"":[""EDR1""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false},{""pmid"":""21605210"",""title"":""Arabidopsis ENHANCED DISEASE RESISTANCE 1 is required for pathogen-induced expression of plant defensins in nonhost resistance, and acts through interference of MYC2-mediated repressor function."",""doi"":""10.1111/j.1365-313x.2011.04651.x"",""url"":""https://pubmed.ncbi.nlm.nih.gov/21605210/"",""year"":""2011"",""journal"":""The Plant journal : for cell and molecular biology"",""authors"":""Hiruma K, Nishiuchi T, Kato T, Bednarek P, Okuno T, Schulze-Lefert P, Takano Y."",""matched_aliases"":[""EDR1""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false},{""pmid"":""21726375"",""title"":""Negative regulation of defence signalling pathways by the EDR1 protein kinase."",""doi"":""10.1111/j.1364-3703.2011.00708.x"",""url"":""https://pubmed.ncbi.nlm.nih.gov/21726375/"",""year"":""2011"",""journal"":""Molecular plant pathology"",""authors"":""Christiansen KM, Gu Y, Rodibaugh N, Innes RW."",""matched_aliases"":[""EDR1""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false},{""pmid"":""9634583"",""title"":""An Arabidopsis mutant with enhanced resistance to powdery mildew."",""doi"":""10.1105/tpc.10.6.947"",""url"":""https://pubmed.ncbi.nlm.nih.gov/9634583/"",""year"":""1998"",""journal"":""The Plant cell"",""authors"":""Frye CA, Innes RW."",""matched_aliases"":[""EDR1""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false}]"
LXL04_005410	gene-LXL04_005410	KAL4592416.1	OH-1004	3	Q05609	CTR1_ARATH	Swiss-Prot		Serine/threonine-protein kinase CTR1 OS=Arabidopsis thaliana OX=3702 GN=CTR1 PE=1 SV=1	Arabidopsis thaliana	CTR1	57.091	275	35.271	4.52e-101	333.0	weak_database_homology	BLASTP to reviewed UniProt Swiss-Prot	UniProt Swiss-Prot current_release 2026-06-10	At5g03730	在乙烯反应途径中充当负调节剂。	Acts as a negative regulator in the ethylene response pathway.	"[{""pmid"":""23132950"",""title"":""CTR1 phosphorylates the central regulator EIN2 to control ethylene hormone signaling from the ER membrane to the nucleus in Arabidopsis."",""doi"":""10.1073/pnas.1214848109"",""url"":""https://pubmed.ncbi.nlm.nih.gov/23132950/"",""year"":""2012"",""journal"":""Proceedings of the National Academy of Sciences of the United States of America"",""authors"":""Ju C, Yoon GM, Shemansky JM, Lin DY, Ying ZI, Chang J, Garrett WM, Kessenbrock M, Groth G, Tucker ML, Cooper B, Kieber JJ, Chang C."",""matched_aliases"":[""CTR1""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false},{""pmid"":""25822663"",""title"":""Unsaturation of very-long-chain ceramides protects plant from hypoxia-induced damages by modulating ethylene signaling in Arabidopsis."",""doi"":""10.1371/journal.pgen.1005143"",""url"":""https://pubmed.ncbi.nlm.nih.gov/25822663/"",""year"":""2015"",""journal"":""PLoS genetics"",""authors"":""Xie LJ, Chen QF, Chen MX, Yu LJ, Huang L, Chen L, Wang FZ, Xia FN, Zhu TR, Wu JX, Yin J, Liao B, Shi J, Zhang JH, Aharoni A, Yao N, Shu W, Xiao S."",""matched_aliases"":[""CTR1""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false},{""pmid"":""8431946"",""title"":""CTR1, a negative regulator of the ethylene response pathway in Arabidopsis, encodes a member of the raf family of protein kinases."",""doi"":""10.1016/0092-8674(93)90119-b"",""url"":""https://pubmed.ncbi.nlm.nih.gov/8431946/"",""year"":""1993"",""journal"":""Cell"",""authors"":""Kieber JJ, Rothenberg M, Roman G, Feldmann KA, Ecker JR."",""matched_aliases"":[""CTR1""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false}]"