query	query_gene_id	query_protein_id	source_reference	hit_rank	swissprot_acc	swissprot_entry	database_section	target_gene_id	description	organism	homolog_gene_name	percent_identity	alignment_length	query_coverage	evalue	bitscore	confidence	evidence_type	source_db	reference_gene_id	reference_function_zh	reference_function_en	reference_papers_json
TkA05G398130	TkA05G398130	TkA05G398130.1	TK1151	1	Q9FX43	M2K9_ARATH	Swiss-Prot		sp|Q9FX43|M2K9_ARATH Mitogen-activated protein kinase kinase 9	Arabidopsis thaliana	MKK9	66.5	319	99.051	1.56e-142	407.0	High	TK1151 direct protein BLASTP	UniProt Swiss-Prot local database (DIAMOND)	At1g73500	MKK9-MPK3/MPK6 模块磷酸化并激活 EIN3，从而促进乙烯信号传导中 EIN3 介导的转录。	MKK9-MPK3/MPK6 module phosphorylates and activates EIN3, leading to the promotion of EIN3-mediated transcription in ethylene signaling.	"[{""pmid"":""18273012"",""title"":""Dual control of nuclear EIN3 by bifurcate MAPK cascades in C2H4 signalling."",""doi"":""10.1038/nature06543"",""url"":""https://pubmed.ncbi.nlm.nih.gov/18273012/"",""year"":""2008"",""journal"":""Nature"",""authors"":""Yoo SD, Cho YH, Tena G, Xiong Y, Sheen J."",""matched_aliases"":[""MKK9""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false},{""pmid"":""18693252"",""title"":""Activation of MAPK kinase 9 induces ethylene and camalexin biosynthesis and enhances sensitivity to salt stress in Arabidopsis."",""doi"":""10.1074/jbc.m801392200"",""url"":""https://pubmed.ncbi.nlm.nih.gov/18693252/"",""year"":""2008"",""journal"":""The Journal of biological chemistry"",""authors"":""Xu J, Li Y, Wang Y, Liu H, Lei L, Yang H, Liu G, Ren D."",""matched_aliases"":[""MKK9""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false},{""pmid"":""19251906"",""title"":""An arabidopsis mitogen-activated protein kinase cascade, MKK9-MPK6, plays a role in leaf senescence."",""doi"":""10.1104/pp.108.133439"",""url"":""https://pubmed.ncbi.nlm.nih.gov/19251906/"",""year"":""2009"",""journal"":""Plant physiology"",""authors"":""Zhou C, Cai Z, Guo Y, Gan S."",""matched_aliases"":[""MKK9""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false}]"
TkA05G398130	TkA05G398130	TkA05G398130.1	TK1151	2	Q9LPQ3	M2K7_ARATH	Swiss-Prot		sp|Q9LPQ3|M2K7_ARATH Mitogen-activated protein kinase kinase 7	Arabidopsis thaliana	MKK7	60.9	317	99.051	3.31e-129	373.0	High	TK1151 direct protein BLASTP	UniProt Swiss-Prot local database (DIAMOND)	At1g18350	可能充当极性生长素运输的负调节剂。	May function as a negative regulator of polar auxin transport.	"[{""pmid"":""16377756"",""title"":""Increased expression of MAP KINASE KINASE7 causes deficiency in polar auxin transport and leads to plant architectural abnormality in Arabidopsis."",""doi"":""10.1105/tpc.105.037846"",""url"":""https://pubmed.ncbi.nlm.nih.gov/16377756/"",""year"":""2006"",""journal"":""The Plant cell"",""authors"":""Dai Y, Wang H, Li B, Huang J, Liu X, Zhou Y, Mou Z, Li J."",""matched_aliases"":[""BUD1"",""MKK7""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false},{""pmid"":""17908155"",""title"":""Overexpression of Arabidopsis MAP kinase kinase 7 leads to activation of plant basal and systemic acquired resistance."",""doi"":""10.1111/j.1365-313x.2007.03294.x"",""url"":""https://pubmed.ncbi.nlm.nih.gov/17908155/"",""year"":""2007"",""journal"":""The Plant journal : for cell and molecular biology"",""authors"":""Zhang X, Dai Y, Xiong Y, DeFraia C, Li J, Dong X, Mou Z."",""matched_aliases"":[""BUD1"",""MKK7""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false}]"
TkA05G398130	TkA05G398130	TkA05G398130.1	TK1151	3	Q9M8J5	M2K8_ARATH	Swiss-Prot		sp|Q9M8J5|M2K8_ARATH Mitogen-activated protein kinase kinase 8	Arabidopsis thaliana	MKK8	53.4	292	90.506	2.34e-100	300.0	High	TK1151 direct protein BLASTP	UniProt Swiss-Prot local database (DIAMOND)	At3g06230	促丝裂原活化蛋白激酶激酶8。	Mitogen-activated protein kinase kinase 8.	[]
TkA05G398130	TkA05G398130	TkA05G398130.1	TK1151	4	Q8RXG3	M2K5_ARATH	Swiss-Prot		sp|Q8RXG3|M2K5_ARATH Mitogen-activated protein kinase kinase 5	Arabidopsis thaliana	MKK5	53.2	263	83.228	7.7e-98	295.0	High	TK1151 direct protein BLASTP	UniProt Swiss-Prot local database (DIAMOND)	At3g21220	丝裂原激活蛋白激酶激酶 ，可调节参与根生长和气孔反应的 MAPKKK20-MKK5-MPK6 级联中的脱落酸 反应，可能是通过蛋白质磷酸化激活 MAPK6 来实现的。	Mitogen-activated protein kinase kinase (MAPKK) which regulates abscisic acid (ABA) responses in a MAPKKK20-MKK5-MPK6 cascade involved in root growth (e.g. root cell division and elongation) and stomatal response, probably via MAPK6 activation by protein phosphorylation.	"[{""pmid"":""11687590"",""title"":""Cell death mediated by MAPK is associated with hydrogen peroxide production in Arabidopsis."",""doi"":""10.1074/jbc.m109495200"",""url"":""https://pubmed.ncbi.nlm.nih.gov/11687590/"",""year"":""2002"",""journal"":""The Journal of biological chemistry"",""authors"":""Ren D, Yang H, Zhang S."",""matched_aliases"":[""AtMEK5""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false},{""pmid"":""11875555"",""title"":""MAP kinase signalling cascade in Arabidopsis innate immunity."",""doi"":""10.1038/415977a"",""url"":""https://pubmed.ncbi.nlm.nih.gov/11875555/"",""year"":""2002"",""journal"":""Nature"",""authors"":""Asai T, Tena G, Plotnikova J, Willmann MR, Chiu WL, Gomez-Gomez L, Boller T, Ausubel FM, Sheen J."",""matched_aliases"":[""MKK5""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false},{""pmid"":""17259259"",""title"":""Stomatal development and patterning are regulated by environmentally responsive mitogen-activated protein kinases in Arabidopsis."",""doi"":""10.1105/tpc.106.048298"",""url"":""https://pubmed.ncbi.nlm.nih.gov/17259259/"",""year"":""2007"",""journal"":""The Plant cell"",""authors"":""Wang H, Ngwenyama N, Liu Y, Walker JC, Zhang S."",""matched_aliases"":[""MKK5""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false},{""pmid"":""18268539"",""title"":""Ethylene signaling is required for the acceleration of cell death induced by the activation of AtMEK5 in Arabidopsis."",""doi"":""10.1038/cr.2008.29"",""url"":""https://pubmed.ncbi.nlm.nih.gov/18268539/"",""year"":""2008"",""journal"":""Cell research"",""authors"":""Liu H, Wang Y, Xu J, Su T, Liu G, Ren D."",""matched_aliases"":[""AtMEK5""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false},{""pmid"":""18809915"",""title"":""Regulation of floral organ abscission in Arabidopsis thaliana."",""doi"":""10.1073/pnas.0805539105"",""url"":""https://pubmed.ncbi.nlm.nih.gov/18809915/"",""year"":""2008"",""journal"":""Proceedings of the National Academy of Sciences of the United States of America"",""authors"":""Cho SK, Larue CT, Chevalier D, Wang H, Jinn TL, Zhang S, Walker JC."",""matched_aliases"":[""MKK5""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false},{""pmid"":""20571112"",""title"":""A Pseudomonas syringae ADP-ribosyltransferase inhibits Arabidopsis mitogen-activated protein kinase kinases."",""doi"":""10.1105/tpc.110.075697"",""url"":""https://pubmed.ncbi.nlm.nih.gov/20571112/"",""year"":""2010"",""journal"":""The Plant cell"",""authors"":""Wang Y, Li J, Hou S, Wang X, Li Y, Ren D, Chen S, Tang X, Zhou JM."",""matched_aliases"":[""MKK5""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false},{""pmid"":""23263767"",""title"":""A MAPK cascade downstream of ERECTA receptor-like protein kinase regulates Arabidopsis inflorescence architecture by promoting localized cell proliferation."",""doi"":""10.1105/tpc.112.104695"",""url"":""https://pubmed.ncbi.nlm.nih.gov/23263767/"",""year"":""2012"",""journal"":""The Plant cell"",""authors"":""Meng X, Wang H, He Y, Liu Y, Walker JC, Torii KU, Zhang S."",""matched_aliases"":[""MKK5""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false},{""pmid"":""23341468"",""title"":""Brassinosteroid-regulated GSK3/Shaggy-like kinases phosphorylate mitogen-activated protein (MAP) kinase kinases, which control stomata development in Arabidopsis thaliana."",""doi"":""10.1074/jbc.m112.384453"",""url"":""https://pubmed.ncbi.nlm.nih.gov/23341468/"",""year"":""2013"",""journal"":""The Journal of biological chemistry"",""authors"":""Khan M, Rozhon W, Bigeard J, Pflieger D, Husar S, Pitzschke A, Teige M, Jonak C, Hirt H, Poppenberger B."",""matched_aliases"":[""MKK5""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false},{""pmid"":""23677921"",""title"":""MKK5 regulates high light-induced gene expression of Cu/Zn superoxide dismutase 1 and 2 in Arabidopsis."",""doi"":""10.1093/pcp/pct072"",""url"":""https://pubmed.ncbi.nlm.nih.gov/23677921/"",""year"":""2013"",""journal"":""Plant & cell physiology"",""authors"":""Xing Y, Cao Q, Zhang Q, Qin L, Jia W, Zhang J."",""matched_aliases"":[""MKK5""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false},{""pmid"":""24019147"",""title"":""Identification of BZR1-interacting proteins as potential components of the brassinosteroid signaling pathway in Arabidopsis through tandem affinity purification."",""doi"":""10.1074/mcp.m113.029256"",""url"":""https://pubmed.ncbi.nlm.nih.gov/24019147/"",""year"":""2013"",""journal"":""Molecular & cellular proteomics : MCP"",""authors"":""Wang C, Shang JX, Chen QX, Oses-Prieto JA, Bai MY, Yang Y, Yuan M, Zhang YL, Mu CC, Deng Z, Wei CQ, Burlingame AL, Wang ZY, Sun Y."",""matched_aliases"":[""MKK5""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false},{""pmid"":""27913741"",""title"":""AIK1, A Mitogen-Activated Protein Kinase, Modulates Abscisic Acid Responses through the MKK5-MPK6 Kinase Cascade."",""doi"":""10.1104/pp.16.01386"",""url"":""https://pubmed.ncbi.nlm.nih.gov/27913741/"",""year"":""2017"",""journal"":""Plant physiology"",""authors"":""Li K, Yang F, Zhang G, Song S, Li Y, Ren D, Miao Y, Song CP."",""matched_aliases"":[""MKK5""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false}]"
TkA05G398130	TkA05G398130	TkA05G398130.1	TK1151	5	O80397	M2K4_ARATH	Swiss-Prot		sp|O80397|M2K4_ARATH Mitogen-activated protein kinase kinase 4	Arabidopsis thaliana	MKK4	48.8	324	96.835	3.87e-97	294.0	Medium	TK1151 direct protein BLASTP	UniProt Swiss-Prot local database (DIAMOND)	At1g51660	参与高敏感反应样细胞死亡期间过氧化氢生成的第二阶段。	Involved in the second phase of hydrogen peroxide generation during hypersensitive response-like cell death.	"[{""pmid"":""11875555"",""title"":""MAP kinase signalling cascade in Arabidopsis innate immunity."",""doi"":""10.1038/415977a"",""url"":""https://pubmed.ncbi.nlm.nih.gov/11875555/"",""year"":""2002"",""journal"":""Nature"",""authors"":""Asai T, Tena G, Plotnikova J, Willmann MR, Chiu WL, Gomez-Gomez L, Boller T, Ausubel FM, Sheen J."",""matched_aliases"":[""MKK4""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false},{""pmid"":""17259259"",""title"":""Stomatal development and patterning are regulated by environmentally responsive mitogen-activated protein kinases in Arabidopsis."",""doi"":""10.1105/tpc.106.048298"",""url"":""https://pubmed.ncbi.nlm.nih.gov/17259259/"",""year"":""2007"",""journal"":""The Plant cell"",""authors"":""Wang H, Ngwenyama N, Liu Y, Walker JC, Zhang S."",""matched_aliases"":[""MKK4""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false},{""pmid"":""18809915"",""title"":""Regulation of floral organ abscission in Arabidopsis thaliana."",""doi"":""10.1073/pnas.0805539105"",""url"":""https://pubmed.ncbi.nlm.nih.gov/18809915/"",""year"":""2008"",""journal"":""Proceedings of the National Academy of Sciences of the United States of America"",""authors"":""Cho SK, Larue CT, Chevalier D, Wang H, Jinn TL, Zhang S, Walker JC."",""matched_aliases"":[""MKK4""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false},{""pmid"":""21806969"",""title"":""Arabidopsis MKK4 mediates osmotic-stress response via its regulation of MPK3 activity."",""doi"":""10.1016/j.bbrc.2011.07.064"",""url"":""https://pubmed.ncbi.nlm.nih.gov/21806969/"",""year"":""2011"",""journal"":""Biochemical and biophysical research communications"",""authors"":""Kim SH, Woo DH, Kim JM, Lee SY, Chung WS, Moon YH."",""matched_aliases"":[""MKK4""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false},{""pmid"":""23263767"",""title"":""A MAPK cascade downstream of ERECTA receptor-like protein kinase regulates Arabidopsis inflorescence architecture by promoting localized cell proliferation."",""doi"":""10.1105/tpc.112.104695"",""url"":""https://pubmed.ncbi.nlm.nih.gov/23263767/"",""year"":""2012"",""journal"":""The Plant cell"",""authors"":""Meng X, Wang H, He Y, Liu Y, Walker JC, Torii KU, Zhang S."",""matched_aliases"":[""MKK4""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false},{""pmid"":""23341468"",""title"":""Brassinosteroid-regulated GSK3/Shaggy-like kinases phosphorylate mitogen-activated protein (MAP) kinase kinases, which control stomata development in Arabidopsis thaliana."",""doi"":""10.1074/jbc.m112.384453"",""url"":""https://pubmed.ncbi.nlm.nih.gov/23341468/"",""year"":""2013"",""journal"":""The Journal of biological chemistry"",""authors"":""Khan M, Rozhon W, Bigeard J, Pflieger D, Husar S, Pitzschke A, Teige M, Jonak C, Hirt H, Poppenberger B."",""matched_aliases"":[""MKK4""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false}]"