query	query_gene_id	query_protein_id	source_reference	hit_rank	swissprot_acc	swissprot_entry	database_section	target_gene_id	description	organism	homolog_gene_name	percent_identity	alignment_length	query_coverage	evalue	bitscore	confidence	evidence_type	source_db	reference_gene_id	reference_function_zh	reference_function_en	reference_papers_json
LXL04_012029	gene-LXL04_012029	KAL4575942.1	OH-1004	1	Q9SB38	PMEI4_ARATH	Swiss-Prot		Pectinesterase inhibitor 4 OS=Arabidopsis thaliana OX=3702 GN=PMEI4 PE=1 SV=1	Arabidopsis thaliana	PMEI4	32.984	191	97.396	3.43e-34	123.0	moderate_database_homology	BLASTP to reviewed UniProt Swiss-Prot	UniProt Swiss-Prot current_release 2026-06-10	At4g25250	果胶甲基酯酶（PME）抑制剂，可靶向根系表达的PME17和PME3，其作用依赖于pH值，主要在略酸性条件下（pH 6.3和5.0）起作用，但在pH 7.5时不发生作用；该过程依赖于参与分子间和分子内相互作用的氨基酸质子化状态的变化。	Pectin methylesterase (PME) inhibitor that can target the root-expressed PME17 and PME3 in a pH-dependent manner, mainly in slightly acidic conditions (pH 6.3 and 5.0) but not at pH 7.5; this processus relies on changes in the protonation of amino acids involved in intermolecular and intramolecular interactions.	"[{""pmid"":""25826258"",""title"":""Arabidopsis PME17 Activity can be Controlled by Pectin Methylesterase Inhibitor4."",""doi"":""10.4161/15592324.2014.983351"",""url"":""https://pubmed.ncbi.nlm.nih.gov/25826258/"",""year"":""2015"",""journal"":""Plant signaling & behavior"",""authors"":""Sénéchal F; Mareck A; Marcelo P; Lerouge P; Pelloux J"",""matched_aliases"":[""PMEI4""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed""],""fulltext_reviewed"":false},{""pmid"":""28034952"",""title"":""Combined Experimental and Computational Approaches Reveal Distinct pH Dependence of Pectin Methylesterase Inhibitors."",""doi"":""10.1104/pp.16.01790"",""url"":""https://pubmed.ncbi.nlm.nih.gov/28034952/"",""year"":""2017"",""journal"":""Plant physiology"",""authors"":""Hocq L, Sénéchal F, Lefebvre V, Lehner A, Domon JM, Mollet JC, Dehors J, Pageau K, Marcelo P, Guérineau F, Kolšek K, Mercadante D, Pelloux J."",""matched_aliases"":[""AtPMEI4""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false}]"
LXL04_012029	gene-LXL04_012029	KAL4575942.1	OH-1004	3	Q9SB37	PMEI7_ARATH	Swiss-Prot		Pectinesterase inhibitor 7 OS=Arabidopsis thaliana OX=3702 GN=PMEI7 PE=1 SV=1	Arabidopsis thaliana	PMEI7	33.862	189	96.354	3.19e-33	120.0	moderate_database_homology	BLASTP to reviewed UniProt Swiss-Prot	UniProt Swiss-Prot current_release 2026-06-10	At4g25260	果胶甲酯酶 抑制剂，可以以 pH 依赖性方式靶向 PME3，主要在弱酸性条件下但不在 pH 7.0 下。	Pectin methylesterase (PME) inhibitor that can target PME3 in a pH-dependent manner, mainly in slightly acidic conditions (pH 6.0 and 5.0) but not at pH 7.0.	"[{""pmid"":""26183897"",""title"":""Tuning of Pectin Methylesterification: PECTIN METHYLESTERASE INHIBITOR 7 MODULATES THE PROCESSIVE ACTIVITY OF CO-EXPRESSED PECTIN METHYLESTERASE 3 IN A pH-DEPENDENT MANNER."",""doi"":""10.1074/jbc.m115.639534"",""url"":""https://pubmed.ncbi.nlm.nih.gov/26183897/"",""year"":""2015"",""journal"":""The Journal of biological chemistry"",""authors"":""Sénéchal F, L'Enfant M, Domon JM, Rosiau E, Crépeau MJ, Surcouf O, Esquivel-Rodriguez J, Marcelo P, Mareck A, Guérineau F, Kim HR, Mravec J, Bonnin E, Jamet E, Kihara D, Lerouge P, Ralet MC, Pelloux J, Rayon C."",""matched_aliases"":[""AtPMEI7""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false},{""pmid"":""29109147"",""title"":""Structural and dynamical characterization of the pH-dependence of the pectin methylesterase-pectin methylesterase inhibitor complex."",""doi"":""10.1074/jbc.ra117.000197"",""url"":""https://pubmed.ncbi.nlm.nih.gov/29109147/"",""year"":""2017"",""journal"":""The Journal of biological chemistry"",""authors"":""Sénéchal F, Habrylo O, Hocq L, Domon JM, Marcelo P, Lefebvre V, Pelloux J, Mercadante D."",""matched_aliases"":[""PMEI7""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false}]"
LXL04_012029	gene-LXL04_012029	KAL4575942.1	OH-1004	4	Q9STY5	PMI11_ARATH	Swiss-Prot		Pectinesterase inhibitor 11 OS=Arabidopsis thaliana OX=3702 GN=PMEI11 PE=2 SV=1	Arabidopsis thaliana	PMEI11	37.234	188	95.312	5.93e-33	119.0	moderate_database_homology	BLASTP to reviewed UniProt Swiss-Prot	UniProt Swiss-Prot current_release 2026-06-10	At3g47380	果胶甲酯酶（PME）抑制剂，参与对坏死性病原体反应中的细胞壁完整性维持。	Pectin methylesterase (PME) inhibitor involved in the maintenance of cell wall integrity in response to necrotrophic pathogens.	[]
LXL04_012029	gene-LXL04_012029	KAL4575942.1	OH-1004	5	Q9SI74	PMI10_ARATH	Swiss-Prot		Pectinesterase inhibitor 10 OS=Arabidopsis thaliana OX=3702 GN=PMEI10 PE=2 SV=1	Arabidopsis thaliana	PMEI10	38.608	158	81.25	1.66e-31	119.0	moderate_database_homology	BLASTP to reviewed UniProt Swiss-Prot	UniProt Swiss-Prot current_release 2026-06-10	At1g62760	果胶甲酯酶（PME）抑制剂，参与对坏死性病原体反应中的细胞壁完整性维持。	Pectin methylesterase (PME) inhibitor involved in the maintenance of cell wall integrity in response to necrotrophic pathogens.	[]