query gene_id record_type id name namespace_or_position evidence source query_reference annotation_reference annotation_gene_id annotation_assembly mapping_category mapped_annotation TkA03G200980 TkA03G200980 function TkA03G200980 Similar to CSI1: Protein CELLULOSE SYNTHASE INTERACTIVE 1 (Arabidopsis thaliana OX%3D3702) GFF-derived GCA_047496595.1_OSU_TarKok_2.0 TK1151 OH1004 LXL04_007479 GCA_047496595.1_OSU_TarKok_2.0 many_to_one True TkA03G200980 TkA03G200980 GO GO:0007166 cell surface receptor signaling pathway biological_process Swiss-Prot reviewed homolog transfer; hit_rank=5; identity=32.474; coverage=8.92; evalue=1.37e-08; UniProt GO evidence=IEA:InterPro UniProtKB/Swiss-Prot DAT 2026 current_release TK1151 OH1004 LXL04_007479 GCA_047496595.1_OSU_TarKok_2.0 many_to_one True TkA03G200980 TkA03G200980 GO GO:0008360 regulation of cell shape biological_process Swiss-Prot reviewed homolog transfer; hit_rank=1; identity=75.925; coverage=100.644; evalue=0.0; UniProt GO evidence=IEA:UniProtKB-KW UniProtKB/Swiss-Prot DAT 2026 current_release TK1151 OH1004 LXL04_007479 GCA_047496595.1_OSU_TarKok_2.0 many_to_one True TkA03G200980 TkA03G200980 GO GO:0009414 response to water deprivation biological_process Swiss-Prot reviewed homolog transfer; hit_rank=1; identity=75.925; coverage=100.644; evalue=0.0; UniProt GO evidence=IMP:UniProtKB UniProtKB/Swiss-Prot DAT 2026 current_release TK1151 OH1004 LXL04_007479 GCA_047496595.1_OSU_TarKok_2.0 many_to_one True TkA03G200980 TkA03G200980 GO GO:0009826 unidimensional cell growth biological_process Swiss-Prot reviewed homolog transfer; hit_rank=2; identity=47.037; coverage=96.966; evalue=0.0; UniProt GO evidence=IGI:TAIR UniProtKB/Swiss-Prot DAT 2026 current_release TK1151 OH1004 LXL04_007479 GCA_047496595.1_OSU_TarKok_2.0 many_to_one True TkA03G200980 TkA03G200980 GO GO:0009833 plant-type primary cell wall biogenesis biological_process Swiss-Prot reviewed homolog transfer; hit_rank=1; identity=75.925; coverage=100.644; evalue=0.0; UniProt GO evidence=IMP:UniProtKB UniProtKB/Swiss-Prot DAT 2026 current_release TK1151 OH1004 LXL04_007479 GCA_047496595.1_OSU_TarKok_2.0 many_to_one True TkA03G200980 TkA03G200980 GO GO:0009901 anther dehiscence biological_process Swiss-Prot reviewed homolog transfer; hit_rank=1; identity=75.925; coverage=100.644; evalue=0.0; UniProt GO evidence=IMP:UniProtKB UniProtKB/Swiss-Prot DAT 2026 current_release TK1151 OH1004 LXL04_007479 GCA_047496595.1_OSU_TarKok_2.0 many_to_one True TkA03G200980 TkA03G200980 GO GO:0010208 pollen wall assembly biological_process Swiss-Prot reviewed homolog transfer; hit_rank=1; identity=75.925; coverage=100.644; evalue=0.0; UniProt GO evidence=IMP:UniProtKB UniProtKB/Swiss-Prot DAT 2026 current_release TK1151 OH1004 LXL04_007479 GCA_047496595.1_OSU_TarKok_2.0 many_to_one True TkA03G200980 TkA03G200980 GO GO:0010215 cellulose microfibril organization biological_process Swiss-Prot reviewed homolog transfer; hit_rank=1; identity=75.925; coverage=100.644; evalue=0.0; UniProt GO evidence=IMP:UniProtKB UniProtKB/Swiss-Prot DAT 2026 current_release TK1151 OH1004 LXL04_007479 GCA_047496595.1_OSU_TarKok_2.0 many_to_one True TkA03G200980 TkA03G200980 GO GO:0016567 protein ubiquitination biological_process Swiss-Prot reviewed homolog transfer; hit_rank=4; identity=36.129; coverage=7.126; evalue=7.53e-09; UniProt GO evidence=IMP:TAIR UniProtKB/Swiss-Prot DAT 2026 current_release TK1151 OH1004 LXL04_007479 GCA_047496595.1_OSU_TarKok_2.0 many_to_one True TkA03G200980 TkA03G200980 GO GO:0030244 cellulose biosynthetic process biological_process Swiss-Prot reviewed homolog transfer; hit_rank=1; identity=75.925; coverage=100.644; evalue=0.0; UniProt GO evidence=IMP:UniProtKB UniProtKB/Swiss-Prot DAT 2026 current_release TK1151 OH1004 LXL04_007479 GCA_047496595.1_OSU_TarKok_2.0 many_to_one True TkA03G200980 TkA03G200980 GO GO:0034614 cellular response to reactive oxygen species biological_process Swiss-Prot reviewed homolog transfer; hit_rank=4; identity=36.129; coverage=7.126; evalue=7.53e-09; UniProt GO evidence=IGI:TAIR UniProtKB/Swiss-Prot DAT 2026 current_release TK1151 OH1004 LXL04_007479 GCA_047496595.1_OSU_TarKok_2.0 many_to_one True TkA03G200980 TkA03G200980 GO GO:0042742 defense response to bacterium biological_process Swiss-Prot reviewed homolog transfer; hit_rank=5; identity=32.474; coverage=8.92; evalue=1.37e-08; UniProt GO evidence=IGI:TAIR UniProtKB/Swiss-Prot DAT 2026 current_release TK1151 OH1004 LXL04_007479 GCA_047496595.1_OSU_TarKok_2.0 many_to_one True TkA03G200980 TkA03G200980 GO GO:0043622 cortical microtubule organization biological_process Swiss-Prot reviewed homolog transfer; hit_rank=1; identity=75.925; coverage=100.644; evalue=0.0; UniProt GO evidence=IMP:UniProtKB UniProtKB/Swiss-Prot DAT 2026 current_release TK1151 OH1004 LXL04_007479 GCA_047496595.1_OSU_TarKok_2.0 many_to_one True TkA03G200980 TkA03G200980 GO GO:0048364 root development biological_process Swiss-Prot reviewed homolog transfer; hit_rank=4; identity=36.129; coverage=7.126; evalue=7.53e-09; UniProt GO evidence=IGI:TAIR UniProtKB/Swiss-Prot DAT 2026 current_release TK1151 OH1004 LXL04_007479 GCA_047496595.1_OSU_TarKok_2.0 many_to_one True TkA03G200980 TkA03G200980 GO GO:0048467 gynoecium development biological_process Swiss-Prot reviewed homolog transfer; hit_rank=1; identity=75.925; coverage=100.644; evalue=0.0; UniProt GO evidence=IMP:UniProtKB UniProtKB/Swiss-Prot DAT 2026 current_release TK1151 OH1004 LXL04_007479 GCA_047496595.1_OSU_TarKok_2.0 many_to_one True TkA03G200980 TkA03G200980 GO GO:0048658 anther wall tapetum development biological_process Swiss-Prot reviewed homolog transfer; hit_rank=4; identity=36.129; coverage=7.126; evalue=7.53e-09; UniProt GO evidence=IMP:TAIR UniProtKB/Swiss-Prot DAT 2026 current_release TK1151 OH1004 LXL04_007479 GCA_047496595.1_OSU_TarKok_2.0 many_to_one True TkA03G200980 TkA03G200980 GO GO:0048868 pollen tube development biological_process Swiss-Prot reviewed homolog transfer; hit_rank=1; identity=75.925; coverage=100.644; evalue=0.0; UniProt GO evidence=IMP:UniProtKB UniProtKB/Swiss-Prot DAT 2026 current_release TK1151 OH1004 LXL04_007479 GCA_047496595.1_OSU_TarKok_2.0 many_to_one True TkA03G200980 TkA03G200980 GO GO:0050777 negative regulation of immune response biological_process Swiss-Prot reviewed homolog transfer; hit_rank=5; identity=32.474; coverage=8.92; evalue=1.37e-08; UniProt GO evidence=IGI:TAIR UniProtKB/Swiss-Prot DAT 2026 current_release TK1151 OH1004 LXL04_007479 GCA_047496595.1_OSU_TarKok_2.0 many_to_one True TkA03G200980 TkA03G200980 GO GO:0051211 anisotropic cell growth biological_process Swiss-Prot reviewed homolog transfer; hit_rank=1; identity=75.925; coverage=100.644; evalue=0.0; UniProt GO evidence=IMP:UniProtKB UniProtKB/Swiss-Prot DAT 2026 current_release TK1151 OH1004 LXL04_007479 GCA_047496595.1_OSU_TarKok_2.0 many_to_one True TkA03G200980 TkA03G200980 GO GO:0051592 response to calcium ion biological_process Swiss-Prot reviewed homolog transfer; hit_rank=1; identity=75.925; coverage=100.644; evalue=0.0; UniProt GO evidence=IMP:UniProtKB UniProtKB/Swiss-Prot DAT 2026 current_release TK1151 OH1004 LXL04_007479 GCA_047496595.1_OSU_TarKok_2.0 many_to_one True TkA03G200980 TkA03G200980 GO GO:0052324 plant-type cell wall cellulose biosynthetic process biological_process Swiss-Prot reviewed homolog transfer; hit_rank=2; identity=47.037; coverage=96.966; evalue=0.0; UniProt GO evidence=IGI:TAIR UniProtKB/Swiss-Prot DAT 2026 current_release TK1151 OH1004 LXL04_007479 GCA_047496595.1_OSU_TarKok_2.0 many_to_one True TkA03G200980 TkA03G200980 GO GO:0070507 regulation of microtubule cytoskeleton organization biological_process Swiss-Prot reviewed homolog transfer; hit_rank=1; identity=75.925; coverage=100.644; evalue=0.0; UniProt GO evidence=IMP:UniProtKB UniProtKB/Swiss-Prot DAT 2026 current_release TK1151 OH1004 LXL04_007479 GCA_047496595.1_OSU_TarKok_2.0 many_to_one True TkA03G200980 TkA03G200980 GO GO:0071555 cell wall organization biological_process Swiss-Prot reviewed homolog transfer; hit_rank=3; identity=39.237; coverage=97.609; evalue=0.0; UniProt GO evidence=IEA:UniProtKB-KW UniProtKB/Swiss-Prot DAT 2026 current_release TK1151 OH1004 LXL04_007479 GCA_047496595.1_OSU_TarKok_2.0 many_to_one True TkA03G200980 TkA03G200980 GO GO:0072699 protein localization to cortical microtubule cytoskeleton biological_process Swiss-Prot reviewed homolog transfer; hit_rank=1; identity=75.925; coverage=100.644; evalue=0.0; UniProt GO evidence=IDA:UniProtKB UniProtKB/Swiss-Prot DAT 2026 current_release TK1151 OH1004 LXL04_007479 GCA_047496595.1_OSU_TarKok_2.0 many_to_one True TkA03G200980 TkA03G200980 GO GO:1904821 chloroplast disassembly biological_process Swiss-Prot reviewed homolog transfer; hit_rank=4; identity=36.129; coverage=7.126; evalue=7.53e-09; UniProt GO evidence=IGI:TAIR UniProtKB/Swiss-Prot DAT 2026 current_release TK1151 OH1004 LXL04_007479 GCA_047496595.1_OSU_TarKok_2.0 many_to_one True TkA03G200980 TkA03G200980 GO GO:2000067 regulation of root morphogenesis biological_process Swiss-Prot reviewed homolog transfer; hit_rank=1; identity=75.925; coverage=100.644; evalue=0.0; UniProt GO evidence=IMP:UniProtKB UniProtKB/Swiss-Prot DAT 2026 current_release TK1151 OH1004 LXL04_007479 GCA_047496595.1_OSU_TarKok_2.0 many_to_one True TkA03G200980 TkA03G200980 GO GO:2001006 regulation of cellulose biosynthetic process biological_process Swiss-Prot reviewed homolog transfer; hit_rank=1; identity=75.925; coverage=100.644; evalue=0.0; UniProt GO evidence=IEA:InterPro UniProtKB/Swiss-Prot DAT 2026 current_release TK1151 OH1004 LXL04_007479 GCA_047496595.1_OSU_TarKok_2.0 many_to_one True TkA03G200980 TkA03G200980 GO GO:0005634 nucleus cellular_component Swiss-Prot reviewed homolog transfer; hit_rank=1; identity=75.925; coverage=100.644; evalue=0.0; UniProt GO evidence=ISM:TAIR UniProtKB/Swiss-Prot DAT 2026 current_release TK1151 OH1004 LXL04_007479 GCA_047496595.1_OSU_TarKok_2.0 many_to_one True TkA03G200980 TkA03G200980 GO GO:0005737 cytoplasm cellular_component Swiss-Prot reviewed homolog transfer; hit_rank=1; identity=75.925; coverage=100.644; evalue=0.0; UniProt GO evidence=IDA:TAIR UniProtKB/Swiss-Prot DAT 2026 current_release TK1151 OH1004 LXL04_007479 GCA_047496595.1_OSU_TarKok_2.0 many_to_one True TkA03G200980 TkA03G200980 GO GO:0005794 Golgi apparatus cellular_component Swiss-Prot reviewed homolog transfer; hit_rank=1; identity=75.925; coverage=100.644; evalue=0.0; UniProt GO evidence=IDA:UniProtKB UniProtKB/Swiss-Prot DAT 2026 current_release TK1151 OH1004 LXL04_007479 GCA_047496595.1_OSU_TarKok_2.0 many_to_one True TkA03G200980 TkA03G200980 GO GO:0005829 cytosol cellular_component Swiss-Prot reviewed homolog transfer; hit_rank=1; identity=75.925; coverage=100.644; evalue=0.0; UniProt GO evidence=HDA:TAIR UniProtKB/Swiss-Prot DAT 2026 current_release TK1151 OH1004 LXL04_007479 GCA_047496595.1_OSU_TarKok_2.0 many_to_one True TkA03G200980 TkA03G200980 GO GO:0005856 cytoskeleton cellular_component Swiss-Prot reviewed homolog transfer; hit_rank=3; identity=39.237; coverage=97.609; evalue=0.0; UniProt GO evidence=IEA:UniProtKB-SubCell UniProtKB/Swiss-Prot DAT 2026 current_release TK1151 OH1004 LXL04_007479 GCA_047496595.1_OSU_TarKok_2.0 many_to_one True TkA03G200980 TkA03G200980 GO GO:0005886 plasma membrane cellular_component Swiss-Prot reviewed homolog transfer; hit_rank=1; identity=75.925; coverage=100.644; evalue=0.0; UniProt GO evidence=IDA:UniProtKB UniProtKB/Swiss-Prot DAT 2026 current_release TK1151 OH1004 LXL04_007479 GCA_047496595.1_OSU_TarKok_2.0 many_to_one True TkA03G200980 TkA03G200980 GO GO:0009506 plasmodesma cellular_component Swiss-Prot reviewed homolog transfer; hit_rank=1; identity=75.925; coverage=100.644; evalue=0.0; UniProt GO evidence=HDA:TAIR UniProtKB/Swiss-Prot DAT 2026 current_release TK1151 OH1004 LXL04_007479 GCA_047496595.1_OSU_TarKok_2.0 many_to_one True TkA03G200980 TkA03G200980 GO GO:0009898 cytoplasmic side of plasma membrane cellular_component Swiss-Prot reviewed homolog transfer; hit_rank=1; identity=75.925; coverage=100.644; evalue=0.0; UniProt GO evidence=IDA:UniProtKB UniProtKB/Swiss-Prot DAT 2026 current_release TK1151 OH1004 LXL04_007479 GCA_047496595.1_OSU_TarKok_2.0 many_to_one True TkA03G200980 TkA03G200980 GO GO:0010330 cellulose synthase complex cellular_component Swiss-Prot reviewed homolog transfer; hit_rank=1; identity=75.925; coverage=100.644; evalue=0.0; UniProt GO evidence=IDA:UniProtKB UniProtKB/Swiss-Prot DAT 2026 current_release TK1151 OH1004 LXL04_007479 GCA_047496595.1_OSU_TarKok_2.0 many_to_one True TkA03G200980 TkA03G200980 GO GO:0012505 endomembrane system cellular_component Swiss-Prot reviewed homolog transfer; hit_rank=2; identity=47.037; coverage=96.966; evalue=0.0; UniProt GO evidence=IEA:UniProtKB-SubCell UniProtKB/Swiss-Prot DAT 2026 current_release TK1151 OH1004 LXL04_007479 GCA_047496595.1_OSU_TarKok_2.0 many_to_one True TkA03G200980 TkA03G200980 GO GO:0036449 microtubule minus-end cellular_component Swiss-Prot reviewed homolog transfer; hit_rank=1; identity=75.925; coverage=100.644; evalue=0.0; UniProt GO evidence=IDA:UniProtKB UniProtKB/Swiss-Prot DAT 2026 current_release TK1151 OH1004 LXL04_007479 GCA_047496595.1_OSU_TarKok_2.0 many_to_one True TkA03G200980 TkA03G200980 GO GO:0055028 cortical microtubule cellular_component Swiss-Prot reviewed homolog transfer; hit_rank=1; identity=75.925; coverage=100.644; evalue=0.0; UniProt GO evidence=IDA:UniProtKB UniProtKB/Swiss-Prot DAT 2026 current_release TK1151 OH1004 LXL04_007479 GCA_047496595.1_OSU_TarKok_2.0 many_to_one True TkA03G200980 TkA03G200980 GO GO:0004842 ubiquitin-protein transferase activity molecular_function Swiss-Prot reviewed homolog transfer; hit_rank=5; identity=32.474; coverage=8.92; evalue=1.37e-08; UniProt GO evidence=IDA:TAIR UniProtKB/Swiss-Prot DAT 2026 current_release TK1151 OH1004 LXL04_007479 GCA_047496595.1_OSU_TarKok_2.0 many_to_one True TkA03G200980 TkA03G200980 GO GO:0008017 microtubule binding molecular_function Swiss-Prot reviewed homolog transfer; hit_rank=1; identity=75.925; coverage=100.644; evalue=0.0; UniProt GO evidence=IDA:UniProtKB UniProtKB/Swiss-Prot DAT 2026 current_release TK1151 OH1004 LXL04_007479 GCA_047496595.1_OSU_TarKok_2.0 many_to_one True TkA03G200980 TkA03G200980 GO GO:0061630 ubiquitin protein ligase activity molecular_function Swiss-Prot reviewed homolog transfer; hit_rank=4; identity=36.129; coverage=7.126; evalue=7.53e-09; UniProt GO evidence=IDA:TAIR UniProtKB/Swiss-Prot DAT 2026 current_release TK1151 OH1004 LXL04_007479 GCA_047496595.1_OSU_TarKok_2.0 many_to_one True TkA03G200980 TkA03G200980 GO GO:0070696 transmembrane receptor protein serine/threonine kinase binding molecular_function Swiss-Prot reviewed homolog transfer; hit_rank=5; identity=32.474; coverage=8.92; evalue=1.37e-08; UniProt GO evidence=IEA:UniProtKB-ARBA UniProtKB/Swiss-Prot DAT 2026 current_release TK1151 OH1004 LXL04_007479 GCA_047496595.1_OSU_TarKok_2.0 many_to_one True TkA03G200980 TkA03G200980 KEGG ath:AT1G44120 KEGG gene cross-reference from reviewed UniProt hit; pathway name pending Swiss-Prot reviewed homolog transfer; hit_rank=3; identity=39.237; coverage=97.609; evalue=0.0 UniProtKB/Swiss-Prot DAT 2026 current_release TK1151 OH1004 LXL04_007479 GCA_047496595.1_OSU_TarKok_2.0 many_to_one True TkA03G200980 TkA03G200980 KEGG ath:AT1G77460 KEGG gene cross-reference from reviewed UniProt hit; pathway name pending Swiss-Prot reviewed homolog transfer; hit_rank=2; identity=47.037; coverage=96.966; evalue=0.0 UniProtKB/Swiss-Prot DAT 2026 current_release TK1151 OH1004 LXL04_007479 GCA_047496595.1_OSU_TarKok_2.0 many_to_one True TkA03G200980 TkA03G200980 KEGG ath:AT2G22125 KEGG gene cross-reference from reviewed UniProt hit; pathway name pending Swiss-Prot reviewed homolog transfer; hit_rank=1; identity=75.925; coverage=100.644; evalue=0.0 UniProtKB/Swiss-Prot DAT 2026 current_release TK1151 OH1004 LXL04_007479 GCA_047496595.1_OSU_TarKok_2.0 many_to_one True TkA03G200980 TkA03G200980 KEGG ath:AT2G23140 KEGG gene cross-reference from reviewed UniProt hit; pathway name pending Swiss-Prot reviewed homolog transfer; hit_rank=4; identity=36.129; coverage=7.126; evalue=7.53e-09 UniProtKB/Swiss-Prot DAT 2026 current_release TK1151 OH1004 LXL04_007479 GCA_047496595.1_OSU_TarKok_2.0 many_to_one True TkA03G200980 TkA03G200980 KEGG ath:AT2G28830 KEGG gene cross-reference from reviewed UniProt hit; pathway name pending Swiss-Prot reviewed homolog transfer; hit_rank=5; identity=32.474; coverage=8.92; evalue=1.37e-08 UniProtKB/Swiss-Prot DAT 2026 current_release TK1151 OH1004 LXL04_007479 GCA_047496595.1_OSU_TarKok_2.0 many_to_one True TkA03G200980 TkA03G200980 organism_homology F4I718 sp|F4I718|CSI3_ARATH Protein CELLULOSE SYNTHASE INTERACTIVE 3 Arabidopsis thaliana identity=56.6; coverage=97.305; evalue=1.24e-315; rank=1 TK1151 Swiss-Prot homology; source_gene=TkA03G200980; source_db=UniProt Swiss-Prot local database (DIAMOND) TK1151 TK1151 TkA03G200980 False TkA03G200980 TkA03G200980 organism_homology_status Oryza sativa 当前查询蛋白的来源表暂无该物种命中；不能据此判断不存在同源。 no_species_hit TK1151 TK1151 TkA03G200980 False TkA03G200980 TkA03G200980 reference_gene_literature At1g77460 微管细胞骨架的调节因子（通过相似性）。 Arabidopsis Cellulose synthase INTERACTIVE3 regulates cellulose biosynthesis in both a microtubule-dependent and microtubule-independent manner in Arabidopsis.; PMID=24368796; DOI=10.1105/tpc.113.116715 https://pubmed.ncbi.nlm.nih.gov/24368796/ TkA03G200980 TkA03G200980 reference_gene_function At1g44120 微管细胞骨架的调控因子。 Arabidopsis 暂无已核实直接文献 TkA03G200980 TkA03G200980 reference_gene_literature At2g22125 微管细胞骨架的调控因子。 Arabidopsis POM-POM2/cellulose synthase interacting1 is essential for the functional association of cellulose synthase and microtubules in Arabidopsis.; PMID=22294619; DOI=10.1105/tpc.111.093575 https://pubmed.ncbi.nlm.nih.gov/22294619/ TkA03G200980 TkA03G200980 reference_gene_literature At2g22125 微管细胞骨架的调控因子。 Arabidopsis The Arabidopsis ARCP protein, CSI1, which is required for microtubule stability, is necessary for root and anther development.; PMID=22427339; DOI=10.1105/tpc.111.095059 https://pubmed.ncbi.nlm.nih.gov/22427339/ TkA03G200980 TkA03G200980 reference_gene_literature At2g22125 微管细胞骨架的调控因子。 Arabidopsis Impaired cellulose synthase guidance leads to stem torsion and twists phyllotactic patterns in Arabidopsis.; PMID=23623553; DOI=10.1016/j.cub.2013.04.013 https://pubmed.ncbi.nlm.nih.gov/23623553/ TkA03G200980 TkA03G200980 reference_gene_literature At2g22125 微管细胞骨架的调控因子。 Arabidopsis Cellulose synthase INTERACTIVE3 regulates cellulose biosynthesis in both a microtubule-dependent and microtubule-independent manner in Arabidopsis.; PMID=24368796; DOI=10.1105/tpc.113.116715 https://pubmed.ncbi.nlm.nih.gov/24368796/ TkA03G200980 TkA03G200980 reference_gene_literature At2g22125 微管细胞骨架的调控因子。 Arabidopsis CESA TRAFFICKING INHIBITOR inhibits cellulose deposition and interferes with the trafficking of cellulose synthase complexes and their associated proteins KORRIGAN1 and POM2/CELLULOSE SYNTHASE INTERACTIVE PROTEIN1.; PMID=25535279; DOI=10.1104/pp.114.249003 https://pubmed.ncbi.nlm.nih.gov/25535279/