物种	参考基因 ID	可能功能	对应论文 / DOI
拟南芥	At3g52430	可能需要 MPK4 下游的脂肪酶来积累植物防御增强分子水杨酸，从而有助于植物针对侵入性生物营养病原体的先天免疫，并有助于识别微生物相关分子模式 后的防御机制。	Arabidopsis thaliana PAD4 encodes a lipase-like gene that is important for salicylic acid signaling.; 1999; DOI: 10.1073/pnas.96.23.13583; PMID: 10557364; https://pubmed.ncbi.nlm.nih.gov/10557364/ | Arabidopsis thaliana EDS4 contributes to salicylic acid (SA)-dependent expression of defense responses: evidence for inhibition of jasmonic acid signaling by SA.; 2000; DOI: 10.1094/mpmi.2000.13.5.503; PMID: 10796016; https://pubmed.ncbi.nlm.nih.gov/10796016/ | Fumonisin B1-induced cell death in arabidopsis protoplasts requires jasmonate-, ethylene-, and salicylate-dependent signaling pathways.; 2000; DOI: 10.1105/tpc.12.10.1823; PMID: 11041879; https://pubmed.ncbi.nlm.nih.gov/11041879/ | Direct interaction between the Arabidopsis disease resistance signaling proteins, EDS1 and PAD4.; 2001; DOI: 10.1093/emboj/20.19.5400; PMID: 11574472; https://pubmed.ncbi.nlm.nih.gov/11574472/ | The disease resistance signaling components EDS1 and PAD4 are essential regulators of the cell death pathway controlled by LSD1 in Arabidopsis.; 2001; DOI: 10.1105/tpc.010085; PMID: 11595797; https://pubmed.ncbi.nlm.nih.gov/11595797/ | EDS5, an essential component of salicylic acid-dependent signaling for disease resistance in Arabidopsis, is a member of the MATE transporter family.; 2002; DOI: 10.1105/tpc.010376; PMID: 11826312; https://pubmed.ncbi.nlm.nih.gov/11826312/ | Arabidopsis RPP4 is a member of the RPP5 multigene family of TIR-NB-LRR genes and confers downy mildew resistance through multiple signalling components.; 2002; DOI: 10.1046/j.0960-7412.2001.01229.x; PMID: 11846877; https://pubmed.ncbi.nlm.nih.gov/11846877/ | Genetic evidence that expression of NahG modifies defence pathways independent of salicylic acid biosynthesis in the Arabidopsis-Pseudomonas syringae pv. tomato interaction.; 2003; DOI: 10.1046/j.1365-313x.2003.01881.x; PMID: 14617091; https://pubmed.ncbi.nlm.nih.gov/14617091/ | LESION SIMULATING DISEASE 1 is required for acclimation to conditions that promote excess excitation energy.; 2004; DOI: 10.1104/pp.104.043646; PMID: 15347794; https://pubmed.ncbi.nlm.nih.gov/15347794/ | A key role for ALD1 in activation of local and systemic defenses in Arabidopsis.; 2004; DOI: 10.1111/j.1365-313x.2004.02200.x; PMID: 15447647; https://pubmed.ncbi.nlm.nih.gov/15447647/ | The atypical resistance gene, RPW8, recruits components of basal defence for powdery mildew resistance in Arabidopsis.; 2005; DOI: 10.1111/j.1365-313x.2005.02356.x; PMID: 15773856; https://pubmed.ncbi.nlm.nih.gov/15773856/ | Arabidopsis SENESCENCE-ASSOCIATED GENE101 stabilizes and signals within an ENHANCED DISEASE SUSCEPTIBILITY1 complex in plant innate immunity.; 2005; DOI: 10.1105/tpc.105.033910; PMID: 16040633; https://pubmed.ncbi.nlm.nih.gov/16040633/ | Premature leaf senescence modulated by the Arabidopsis PHYTOALEXIN DEFICIENT4 gene is associated with defense against the phloem-feeding green peach aphid.; 2005; DOI: 10.1104/pp.105.070433; PMID: 16299172; https://pubmed.ncbi.nlm.nih.gov/16299172/ | Genetic analysis of developmentally regulated resistance to downy mildew (Hyaloperonospora parasitica) in Arabidopsis thaliana.; 2005; DOI: 10.1094/mpmi-18-1226; PMID: 16353557; https://pubmed.ncbi.nlm.nih.gov/16353557/ | Arabidopsis MAP kinase 4 regulates salicylic acid- and jasmonic acid/ethylene-dependent responses via EDS1 and PAD4.; 2006; DOI: 10.1111/j.1365-313x.2006.02806.x; PMID: 16813576; https://pubmed.ncbi.nlm.nih.gov/16813576/ | Plastidial fatty acid levels regulate resistance gene-dependent defense signaling in Arabidopsis.; 2007; DOI: 10.1073/pnas.0609259104; PMID: 17431038; https://pubmed.ncbi.nlm.nih.gov/17431038/ | Phloem-based resistance to green peach aphid is controlled by Arabidopsis PHYTOALEXIN DEFICIENT4 without its signaling partner ENHANCED DISEASE SUSCEPTIBILITY1.; 2007; DOI: 10.1111/j.1365-313x.2007.03241.x; PMID: 17725549; https://pubmed.ncbi.nlm.nih.gov/17725549/ | Lysigenous aerenchyma formation in Arabidopsis is controlled by LESION SIMULATING DISEASE1.; 2007; DOI: 10.1105/tpc.106.048843; PMID: 18055613; https://pubmed.ncbi.nlm.nih.gov/18055613/ | Arabidopsis proteins important for modulating defense responses to Pseudomonas syringae that secrete HopW1-1.; 2008; DOI: 10.1111/j.1365-313x.2008.03439.x; PMID: 18266921; https://pubmed.ncbi.nlm.nih.gov/18266921/ | PAD4-dependent antibiosis contributes to the ssi2-conferred hyper-resistance to the green peach aphid.; 2010; DOI: 10.1094/mpmi-23-5-0618; PMID: 20367470; https://pubmed.ncbi.nlm.nih.gov/20367470/ | Different roles of Enhanced Disease Susceptibility1 (EDS1) bound to and dissociated from Phytoalexin Deficient4 (PAD4) in Arabidopsis immunity.; 2011; DOI: 10.1111/j.1469-8137.2011.03675.x; PMID: 21434927; https://pubmed.ncbi.nlm.nih.gov/21434927/ | SAG101 forms a ternary complex with EDS1 and PAD4 and is required for resistance signaling against turnip crinkle virus.; 2011; DOI: 10.1371/journal.ppat.1002318; PMID: 22072959; https://pubmed.ncbi.nlm.nih.gov/22072959/ | Discrimination of Arabidopsis PAD4 activities in defense against green peach aphid and pathogens.; 2012; DOI: 10.1104/pp.112.193417; PMID: 22353573; https://pubmed.ncbi.nlm.nih.gov/22353573/ | Natural variation in small molecule-induced TIR-NB-LRR signaling induces root growth arrest via EDS1- and PAD4-complexed R protein VICTR in Arabidopsis.; 2012; DOI: 10.1105/tpc.112.107235; PMID: 23275581; https://pubmed.ncbi.nlm.nih.gov/23275581/ | Lesion simulating disease1, enhanced disease susceptibility1, and phytoalexin deficient4 conditionally regulate cellular signaling homeostasis, photosynthesis, water use efficiency, and seed yield in Arabidopsis.; 2013; DOI: 10.1104/pp.112.208116; PMID: 23400705; https://pubmed.ncbi.nlm.nih.gov/23400705/ | Isolation of Arabidopsis mutants with enhanced disease susceptibility by direct screening.; 1996; DOI: 10.1093/genetics/143.2.973; PMID: 8725243; https://pubmed.ncbi.nlm.nih.gov/8725243/ | Phytoalexin-deficient mutants of Arabidopsis reveal that PAD4 encodes a regulatory factor and that four PAD genes contribute to downy mildew resistance.; 1997; DOI: 10.1093/genetics/146.1.381; PMID: 9136026; https://pubmed.ncbi.nlm.nih.gov/9136026/ | PAD4 functions upstream from salicylic acid to control defense responses in Arabidopsis.; 1998; DOI: 10.1105/tpc.10.6.1021; PMID: 9634589; https://pubmed.ncbi.nlm.nih.gov/9634589/ | Correlation of defense gene induction defects with powdery mildew susceptibility in Arabidopsis enhanced disease susceptibility mutants.; 1998; DOI: 10.1046/j.1365-313x.1998.00319.x; PMID: 9881167; https://pubmed.ncbi.nlm.nih.gov/9881167/